阿魏酸甲酯

中文名称:

阿魏酸甲酯

中文同义词:

4-羟基-3-甲氧基肉桂酸甲酯,99%;4-羟基-3-甲氧基肉桂酸甲酯;阿魏酸甲酯 5G

英文名称:

FERULIC ACID METHYL ESTER

英文同义词:

FERULIC ACID METHYL ESTER (METHYL FERULATE);(SYNONYMS: METHYL FERULATE);Methyl Ferulate [4-Hydroxy-3-MethoxycinnaMic Acid Methyl Ester];METHYL 4-HYDROXY-3-METHOXYCINNAMATE;METHYL FERULATE;METHYL TRANS-3-(4-HYDROXY-3-METHOXYPHENYL)-ACRYLATE;METHYL 3-(4-HYDROXY-3-METHOXY)CINNAMATE;FERULIC ACID METHYL ESTER

CAS号:

2309-07-1

分子式:

C11H12O4

分子量:

208.21

EINECS号:

1308068-626-2

相关类别:

原料药;美白防晒;日化用品;植物提取物;医药中间体;医药原料;有机原料;抗衰老剂;原料中间体-原料药;标准品;有机化工原料;Aromatic Esters;原料;标准品;中药对照品

Mol文件:

2309-07-1.mol

熔点 

62-65°C

沸点 

163 °C(Press: 1 Torr)

密度 

1.204±0.06 g/cm3(Predicted)

酸度系数(pKa)

8.88±0.18(Predicted)

水溶解性 

Slightly soluble in water.

CAS 数据库

2309-07-1(CAS DataBase Reference)

NIST化学物质信息

2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, methyl ester(2309-07-1)

生物活性

Ferulic acid methyl ester (Methyl ferulate) 是从 Stemona tuberosa 中分到的阿魏酸衍生物，具有抗氧化、抗炎作用。Ferulic acid methyl ester 能够透过细胞膜和血脑屏障，清除自由基，可用于神经退行性疾病的研究。在原发性骨髓源性巨噬细胞中，Ferulic acid methyl ester 抑制 COX-2 的表达，降低 p-p38 和 p-JNK 的水平。

靶点

p38

p38

体外研究

Ferulic acid methyl ester (25 µg/mL) has no cytotoxic effects on BMDMs after treatment for 6 h, 18 h, 48 h. Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 µg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 µg/mL, in primary bone marrow derived-macrophages (BMDMs). Ferulic acid methyl ester (25 µg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK. Cell Viability Assay Cell Line: Primary bone marrow derived-macrophages (BMDMs) Concentration: 25 µg/mL Incubation Time: 6 h, 18 h, 48 h Result: Showed no cytotoxic effects on BMDMs. Western Blot Analysis Cell Line: RAW 246.7 cells Concentration: 10 µg/mL and 25 µg/mL Incubation Time: For 1 h before stimulation with LPS Result: Significantly suppressed COX-2 expression at 25 µg/mL.

Cell Line:

Primary bone marrow derived-macrophages (BMDMs)

Concentration:

25 µg/mL

Incubation Time:

6 h, 18 h, 48 h

Result:

Showed no cytotoxic effects on BMDMs.

Cell Line:

RAW 246.7 cells

Concentration:

10 µg/mL and 25 µg/mL

Incubation Time:

For 1 h before stimulation with LPS

Result:

Significantly suppressed COX-2 expression at 25 µg/mL.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于番杏科(Aizoaceae) 番杏 Tetragonia tetragonoides (Pall.)O.kuntze 叶。

用途 

阿魏酸甲酯具有杀线虫性；抗炎；抗肿瘤的作用。

用途 

用于含量测定/鉴定/药理实验等

危险类别码 

36/37/38

安全说明 

26-36/37/39

RTECS号

GD9470000