龙胆苦甙

中文名称:

龙胆苦苷

中文同义词:

龙胆苦甙;龙胆苦苷;GENTIOPICROSIDE 龙胆苦苷;龙胆苦苷 20MG;龙胆苦苷(分析标准品);龙胆提取物.龙胆苦甙;龙胆苦苷, 来源有龙胆根;龙胆苦苷(龙胆苦甙)

英文名称:

Gentiopicroside

英文同义词:

1H,3H-Pyrano[3,4-c]pyran-1-one,5-ethenyl-6-(β-D-;glucopyranosyloxy)-5,6-dihydro-,(5R-trans)-;(5R,6S)-5-ethenyl-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,6-dihydro-3H-pyrano[5,4-c]pyran-1-one;1H,3H-Pyrano[3,4-c]pyran-1-one, 5-ethenyl-6-(b-D-glucopyranosyloxy)-5,6-dihydro-, (5R,6S)- ;1H,3H-Pyrano[3,4-c]pyran-1-one, 5-ethenyl-6-(b-D-glucopyranosyloxy)-5,6-dihydro-, (5R-trans)-;(5R)-5β-Ethenyl-6α-(β-D-glucopyranosyloxy)-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one;(5R)-5β-Vinyl-6α-(β-D-glucopyranosyloxy)-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one;GENTIOPICRIN

CAS号:

20831-76-9

分子式:

C16H20O9

分子量:

356.33

EINECS号:

244-070-2

相关类别:

中草药成分;植物提取物;标准品-中药标准品;中药对照品;标准品;对照品,标准品;分析标准品;对照品;植提标准品;中药标准品;医药中间体;小分子抑制剂;小分子抑制剂，天然产物;植物成分单体;单体;标准品-对照品;其他原料;标准品 -中药标准品;Iridoids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;环烯醚萜;分析试剂-对照品;高纯分离试剂;高纯分离试剂-标准品;单体化合物;标准提取物

Mol文件:

20831-76-9.mol

熔点 

191°C

比旋光度 

-200 º (c=2, H2O)

沸点 

667.8±55.0 °C(Predicted)

密度 

1.52±0.1 g/cm3(Predicted)

酸度系数(pKa)

12.79±0.70(Predicted)

CAS 数据库

20831-76-9(CAS DataBase Reference)

生物活性

Gentiopicroside 是一种天然的环烯醚萜苷，能够抑制 P450 的活性，对 CYP2A6 的 IC50 和 Ki 值分别为 61 µM 和 22.8 µM；Gentiopicroside 具有抗炎和抗氧化活性。

靶点

Target Value CYP2A6 (in human liver microsomes) CYP2E1 (in human liver microsomes)

Target

Value

CYP2A6 (in human liver microsomes)

CYP2E1 (in human liver microsomes)

体外研究

Gentiopicroside inhibits P450 activity, with an IC 50 and a K i of 61 µM and 8.12 µM for CYP2A6, also slightly inhibits CYP2E1 activity with an IC 50 of 1.6 mM, but shows no inhibition on CYP1A2 and CYP3A4. Gentiopicroside (12.5, 25 and 50 μM) inhibits RANKL-induced osteoclast formation from mouse bone marrow macrophages (BMMs) in a dose-dependent manner, blocks the expression of osteoclast-related proteins, prevents receptor activator of nuclear factor-κB ligand (RANKL)-triggered JNK and NF-κB activation. Gentiopicroside (50 μM) also inhibits RANKL-induced bone resorption.

体内研究

Gentiopicroside (20, 40, and 80 mg/kg, p.o.) significantly reduces gastric ulcerindex in mice. Gentiopicroside (20, 40, and 80 mg/kg) also ovbiously decreases the levels of HSP-70, TNF-α, IL-6, MDA and increases ncreased GSH level and SOD activity. In addition, Gentiopicroside normalizes EGF and VEGF level in mice.

化学性质 

类白色结晶粉末，易溶于甲醇，几乎不溶于乙醚，来源于长梗秦艽（西藏，甘肃）秦艽根茎 龙胆，苦胆草。

用途 

龙胆苦苷具有利胆、抗炎、健胃、降压的作用。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:具有利胆、抗炎、健胃、降压等作用。

海关编码 

29389090