原薯蓣皂苷

中文名称:

原薯蓣皂甙

中文同义词:

原薯蓣皂苷;刺蒺藜提取物(原薯蓣皂甙);原薯蓣皂甙;原薯蓣皂甙:刺蒺藜提取物;原薯蓣皂苷(标准品);原薯蓣皂素;葫芦巴籽;原薯蓣皂苷(原薯蓣皂素)

英文名称:

Protodioscin

英文同义词:

SHENGMATING;PROTODIOSCIN;PROTODIOSON;26-o-beta-d-glycopyranosyl-22-hydroxyfurost-5-ene-3beta,26-diol-3-o-beta-diglucorhamnoside;PROTODIOSCIN SNAP-N-SHOOT 0.1mg/mL(P);PROTODIOSCIN(P);[(22R,25R)-22-Hydroxy-26-(β-D-glucopyranosyloxy)furosta-5-ene-3β-yl]2-O,4-O-bis(α-L-rhamnopyranosyl)-β-D-glucopyranoside;[(25R)-26-(β-D-Glucopyranosyloxy)-22α-hydroxyfurost-5-en-3β-yl]2-O,4-O-bis(α-L-rhamnopyranosyl)-β-D-glucopyranoside

CAS号:

55056-80-9

分子式:

C51H84O22

分子量:

1049.2

EINECS号:

相关类别:

中草药成分;中药对照品;标准品;对照品,标准品;分析标准品;中药标准品;薯蓣系列;植物提取物;对照品;植提标准品;分析试剂标准品;黄酮;标准品-对照品;标准品-中药标准品;标准品 -中药标准品;分析试剂-标准品;医药原料药;标准品，对照品;Miscellaneous Natural Products;The group of Dioscin;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;医药、农药及染料中间体

Mol文件:

55056-80-9.mol

熔点 

190～192℃

密度 

1.46±0.1 g/cm3(Predicted)

储存条件 

2-8°C

酸度系数(pKa)

12?+-.0.70(Predicted)

CAS 数据库

55056-80-9(CAS DataBase Reference)

概述

原薯蓣皂甙具有很强的生物活性，如能增强男性性功能，对多种癌细胞有毒杀作用，有降血脂，抗白血病等功效。

作用原理

具有自然提升酮睾，增长力量，提高整体竞技状态，无毒副作用，有降血压，降血脂等作用，其中所含的过氧化分解酶，具有明显的抗衰老作用。久服可祛脸上瘢痕，并让肌肤柔嫩润滑。

生物活性

Protodioscin 是山药根茎中主要的甾体皂苷类化合物，具有抗血脂、抗肿瘤，保护心血管等多种功效。

靶点

Human Endogenous Metabolite

Human Endogenous Metabolite

体内研究

Protodioscin (5 and 10 mg/kg) significantly improves glucose intolerance and reduced the levels of serum UA, BUN, Cr, TC and TG. Protodioscin significantly reduces renal concentrations of IL-1β, IL-6 and TNF-α by inhibiting the activation of nuclear factor-κB, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase. Protodioscin ameliorates the death rate, inhibits the increase in neurological deficit scores and infarct volume, and reduces the apoptotic nerve cells induced by MCAO in rats. Protodioscin attenuates the change of relevant apoptins, suppresses the release of pro-inflammatory cytokines in serum and reverses the protein expression of NF-κB (in nucleus and cytoplasm) and IκBα (in cytoplasm) induced by MCAO in rats. Protodioscin (0.5 mg/kg, i.p.) increases the coagulation time by appr 50 % as compared to that of high-fat diet control rats. Protodioscin possesses a promising effect in lowering the blood levels of both lipoproteins, especially LDL, thus resulting in a high ratio of HDL/LDL.

化学性质 

白色结晶性粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于姜科植物闭鞘姜(Costus speciosus Sm.)的根茎，薯蓣科植物盾叶薯蓣(Dioscorea zingiberensis C.H.Wright)的根茎，穿山龙(D.nipponica Makino)的根茎中。

用途 

原薯蓣皂苷具有溶血， 祛痰， 抗血小板聚集， 降血脂的作用。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:细胞毒活性，体内对神经胶质瘤细胞有效。

WGK Germany 

3

海关编码 

29389090