2-脱氧肌苷

中文名称:

2-脱氧肌苷

中文同义词:

2ˊ-脱氧次黄嘌呤核苷;2ˊ-脱氧肌苷;9-(2-脱氧-Β-D-呋喃核糖基)次黄嘌呤;9-(2-脱氧-Β-D-呋喃核糖)黄嘌呤;2-脱氧-肌苷 水合物;2-脱氧-肌苷一水合物;9-(2-脱氧-Β-D-呋喃核糖基)次黄嘌呤2-脱氧次黄嘌呤核苷2-脱氧肌苷;2-脱氧肌苷, 98+%

英文名称:

2-Deoxyinosine

英文同义词:

Didanosine EP Impurity C;Didanosine Impurity Ⅲ:2-Deoxyinosine;Didanosine Impurity 3（Didanosine EP Impurity C）;2-Deoxyinosine;2-Deoxyinosine(Di);DEOXYINOSINE, 2-(RG);9-[(2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-9H-purin-6-ol;9-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

CAS号:

890-38-0

分子式:

C10H12N4O4

分子量:

252.23

EINECS号:

212-964-1

相关类别:

医用原料;核苷;对照品;生化试剂-植物激素及核酸类;生化试剂;核酸;小分子抑制剂;其他生化试剂;化学试剂;Pharmaceutical Raw Materials;Pyridines, Pyrimidines, Purines and Pteredines;Biochemistry;Nucleosides and their analogs;Bases Related Reagents;Heterocycles;Impurities;Inhibitors;Intermediates Fine Chemicals;Nucleotides;Pharmaceuticals;Heterocycles, Impurities, Inhibitors, Nucleotides, Bases Related Reagents, Pharmaceuticals, Intermediates Fine Chemicals;植物激素及核酸类;核苷，核苷酸，寡核苷酸;医用原料;有机溶剂;对照品;中药对照品;Nucleosides, Nucleotides Related Reagents

Mol文件:

890-38-0.mol

熔点 

250 °C

比旋光度 

21 º (c=1, H2O 22 ºC)

沸点 

395.4°C (rough estimate)

密度 

1.3402 (rough estimate)

折射率 

-16 ° (C=1, H2O)

储存条件 

-20°C

酸度系数(pKa)

8.92±0.70(Predicted)

形态

Powder

颜色

White to Off-white

水溶解性 

8.33g/L(25.02 ºC)

BRN 

33517

CAS 数据库

890-38-0(CAS DataBase Reference)

NIST化学物质信息

Inosine, 2-deoxy-(890-38-0)

生物活性

2’-deoxyadenosine 能够抑制人癌细胞株的生长，并发现其与嘌呤核苷磷酸化酶 (PNP) 缺乏有关。

靶点

Human Endogenous Metabolite

Human Endogenous Metabolite

体外研究

In the absence of deoxycoformycin, 2’-deoxyadenosine is primarily deaminated to 2’-deoxyinosine and then converted into hypoxanthine. In the presence of the inhibitor, the deoxynucleoside, in addition to a phosphorylation process, undergoes phosphorolytic cleavage giving rise to adenine. The conversion of 2’-deoxyadenosine to adenine might represent a protective device, emerging when the activity of adenosine deaminase is reduced or inhibited. There is much evidence to indicate that the enzyme catalyzing this processs may be distinct from methylthioadenosine phosphorylase and S-adenosyl homocysteine hydrolase, which are the enzymes reported to be responsible for the formation of adenine from 28-deoxyadenosine in mammals.

化学性质 

白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂。

危险品标志 

Xn,Xi

危险类别码 

20/21/22-36/37/38

安全说明 

24/25-37/39-36-26

WGK Germany 

3

F 

10-23

海关编码 

29349990