N-氧代烟酰胺

中文名称:

N-氧代烟酰胺

中文同义词:

N-氧化烟酰胺;烟碱-N-氧化物;N-氧代烟酰胺;烟酰胺-N-氧化物;烟酰胺氮氧化物;烟碱-N-氧化物,98%;烟酰胺-N-氧化物 N-氧代烟酰胺;尼克酰胺N氧化物

英文名称:

Nicotinamide-N-oxide

英文同义词:

1-OXY-NICOTINAMIDE;3-(AMINOCARBONYL)PYRIDINIUM-1-OLATE;AKOS 94294;NICOTINAMIDE 1-OXIDE;NICOTINAMIDE N-OXIDE;TIMTEC-BB SBB004187;3-Pyridinecarboxamide, 1-oxide;3-Pyridinecarboxamide,1-oxide(9CI)

CAS号:

1986-81-8

分子式:

C6H6N2O2

分子量:

138.12

EINECS号:

217-859-4

相关类别:

生化试剂;医药中间体;核苷，核苷酸，寡核苷酸;小分子抑制剂;无机化工原料;其他原料;生化试剂-维生素;AMIDE;Biochemicals and Reagents;NAD and Analogs;Nucleosides, Nucleotides, Oligonucleotides;Amines;Bases Related Reagents;Heterocycles;Metabolites Impurities;Nicotine Derivatives;Nucleotides;Amines, Heterocycles, Metabolites Impurities, Nicotine Derivatives, Nucleotides, Bases Related Reagents

Mol文件:

1986-81-8.mol

熔点 

291-293 °C (dec.)(lit.)

沸点 

253.51°C (rough estimate)

密度 

1.3471 (rough estimate)

折射率 

1.5100 (estimate)

储存条件 

Inert atmosphere,Room Temperature

酸度系数(pKa)

14.38±0.50(Predicted)

敏感性 

Hygroscopic

CAS 数据库

1986-81-8(CAS DataBase Reference)

生物活性

Nicotinamide N-oxide是生物体内烟酰胺分解代谢物, 是高效选择性的CXCR2受体拮抗剂。

靶点

CXCR2 Human Endogenous Metabolite

CXCR2

Human Endogenous Metabolite

体外研究

Nicotinamide is one of the forms of vitamin B 3 . It is a precursor for nicotinamide adenine dinucleotide, which is best known as an electron carrier in oxidative phosphorylation and as a cofactor for many dehydrogenases. It is metabolized through two enzymatic systems. The first system starts with the methylation of nicotinamide by nicotinamide N-methyltransferase, which can subsequently be oxidized by aldehyde oxidase. The second enzymatic system oxidizes nicotinamide to nicotinamide N-oxide. A series of nicotinamide N-oxides is synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Compound 1 has demonstrated potent inhibition of neutrophil chemotaxis (IC 50 =10 nM). Compound 2 is a selective antagonist of IL-8 binding (IC 50 =110 nM) and potent inhibitor of neutrophil chemotaxis (IC 50 =170 nM).

用途 

烟酰胺N-氧化物是烟酸类相关化合物，用于烟酸相关粒细胞分化的机制的研究 如人类早幼粒细胞性白血病细胞（HL-60）。烟酰胺N-氧化物减少对HL-60细胞株中c-myc的表达。

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

26-36

WGK Germany 

3

海关编码 

29339900