7-氨基放线菌素D

中文名称:

7-氨基放线菌素D

中文同义词:

7-氨基放线菌素D;7-AAD [7-氨基放线菌素 D];7-氨基放线菌素;7-氨基放线菌素D(7-AAD)

英文名称:

7-AMINOACTINOMYCIN D

英文同义词:

7-AAD;7-AMINODACTINOMYCIN;7-AMINOACTINOMYCIN;7-AMINOACTINOMYCIN C1;7-AMINOACTINOMYCIN D;7-AMINO-AMD;7-ADD;7-ACTINOMYCIN C

CAS号:

7240-37-1

分子式:

C62H87N13O16

分子量:

1270.43

EINECS号:

635-285-6

相关类别:

抗生素及抗病毒;荧光探针，标记，颗粒和染色;抗生素;抗癌;生化试剂;医药原料;marker

Mol文件:

7240-37-1.mol

熔点 

252～253℃

沸点 

1400.8±65.0 °C(Predicted)

密度 

1.44

闪点 

801℃

储存条件 

-20°C

溶解度 

chloroform: 1 mg/mL, clear, red

酸度系数(pKa)

8.90±0.70(Predicted)

形态

powder

颜色

red to dark purple

BRN 

5915844

生物活性

7-Aminoactinomycin D (7-AAD) 是一种荧光 DNA 染料，是一种有效的 RNA 聚合酶 (RNA polymerase) 抑制剂。7-Aminoactinomycin D 选择性结合到 DNA 的 GC 区域，还具有抗菌作用。

体外研究

7-Aminoactinomycin D (7-AAD) is a DNA dye that distinguishes viable, apoptotic, and late apoptotic/dead cells in flow cytometry. 7-Aminoactinomycin D staining with 5 μg/mL, 10 μg/mL, and 20 μg/mL, but not with 1 μg/mL, is suitable for quantification of apoptosis in flow cytometry. 7-Aminoactinomycin D is frequently used to stain and exclude dead cells in flow cytometry at low concentrations (0.5-5 μg/mL). At higher concentrations (10-20 μg/mL), 7-Aminoactinomycin D has also been used to distinguish between viable cells (7-AAD negative ) and apoptotic cells (7-AAD dim ) or dead cells (7-AAD bright ) using the fact that permeability of the cell membrane, and hence fluorescence intensity, is low in early apoptotic cells and high in late apoptotic and dead cells.

危险品标志 

T+,T

危险类别码 

26/27/28-36/37/38

安全说明 

26-28-36/37-45

危险品运输编号 

UN 3462 6.1/PG 2

WGK Germany 

3

RTECS号

AU1579000

F 

8-10-21

HazardClass 

6.1(a)

PackingGroup 

II

海关编码 

29419090