盐酸林可霉素(一水物)

中文名称:

盐酸林可霉素(一水物)

中文同义词:

洁霉素盐酸盐;盐酸洁霉素;LINCOMYCIN HYDROCHLORIDE 盐酸林可霉素;林可霉素盐酸盐水合物;盐酸林可霉素一水;盐酸林可霉素(标准品);林可霉素 盐酸盐 一水合物;Y293-盐酸林可霉素

英文名称:

Lincomycin hydrochloride monohydrate

英文同义词:

d-erythro-d-galacto-octopyranoside,methyl6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-,monohydrochloride,hemihydrate;frademicina;lincocinhydrochloridehydrate;lincomycin,hydrochloride,hemihydrate;lincomycin,hydrochloridehydrate;methyl6,8-dideoxy-6-(1-methyl-4-propyl-2-d-erythro-d-galacto-octopyranosid;mycivin;lincocin hydrochlohydrate

CAS号:

7179-49-9

分子式:

C18H37ClN2O7S

分子量:

461.01

EINECS号:

615-424-7

相关类别:

小分子抑制剂;抗生素;生命科学标准品;医药原料;医用原料;兽药原料药;医药原料;原料药;Antibiotics;Interferes with Protein SynthesisAnalytical Standards;LSpectrum of Activity;MLSMore...Close...;Alphabetic;Antibacterial;Antibiotics A to;Antibiotics G-MAntibiotics;Chemical Structure;Chemical Structure Class;L - ZAntibiotics;MacrolidesAntibiotics;Mechanism of Action;中药对照品;原料药;原料;LINCOCIN

Mol文件:

7179-49-9.mol

熔点 

156-158°

比旋光度 

D25 +143° (water)

储存条件 

2-8°C

溶解度 

Very soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in acetone.

形态

neat

Merck 

14,5500

InChIKey

LFZGYTBWUHCAKF-DCNJEFSFSA-N

CAS 数据库

7179-49-9(CAS DataBase Reference)

生物活性

Lincomycin hydrochloride monohydrate 是窄谱抗生素, 具有与红霉素相似的效力, 对革兰氏阳性球菌具有很好的作用效果, 主要抑制细菌细胞蛋白质的合成。

体内研究

Lincomycin (25 and 50 mg/kg, intravenously) depresses neuromuscular transmission to a degree which depended on stimulation frequencies in the rabbit sciatic nerve-gastrocnemius muscle preparation. Animal Model: Adult albino New Zealand rabbits weighing 2.5-3.5 kg. Dosage: 25 and 50 mg/kg. Administration: Intravenously. Result: Depressed neuromuscular transmission.

Animal Model:

Adult albino New Zealand rabbits weighing 2.5-3.5 kg.

Dosage:

25 and 50 mg/kg.

Administration:

Intravenously.

Result:

Depressed neuromuscular transmission.

化学性质 

白色结晶性粉未，微臭，味苦。该药抗菌谱广，无过敏性，穿透力强，是髓炎等骨科病的首选抗菌药物。

用途 

与红霉素相似，对革兰氏阳性菌有强大的抗菌作用。

用途 

与红霉素相似，对革兰阳性菌有强大的抗菌作用

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

26-24/25

WGK Germany 

2

RTECS号

RH6315500

海关编码 

29419090