酒石酸噻吩嘧啶

中文名称:

酒石酸噻吩嘧啶

中文同义词:

酒石酸噻嘧啶;酒石酸噻吩嘧啶

英文名称:

PYRANTEL TARTRATE SALT

英文同义词:

1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)-pyrimidin(e)-pyrimidintartrate;cp10423-18;pyrantel hydrogen tartrate;Pyrantel Tartate;(E)-4,5,6-TETRAHYDRO-1-METHYL-2-(2-(2-THIENYL)ETHENYL)PYRIMIDINE;(E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl)vinyl]pyrimidine tartrate (1:1);PYRANTEL TARTRATE SALT;Pyrantel (+)-tartrate salt,1-Methyl-2-(2-[2-thienyl]ethenyl)-1,4,5,6-tetrahydropyrimidine

CAS号:

33401-94-4

分子式:

C15H20N2O6S

分子量:

356.39

EINECS号:

251-501-8

相关类别:

酒石酸噻吩嘧啶;小分子抑制剂;原料药;化合物;医药原料;化工原料

Mol文件:

33401-94-4.mol

熔点 

148-150°

储存条件 

Inert atmosphere,Room Temperature

溶解度 

H2O: soluble4.0ML, clear, colorless to faint yellow or tan (Solvent: 200 mg plus 4.0 mL )

生物活性

Pyrantel tartrate，一种四氢嘧啶光谱驱虫药，是烟碱乙酰胆碱受体 (nAChR) 激动剂。Pyrantel tartrate 可引起寄生虫的痉挛性肌肉麻痹。Pyrantel tartrate 可用于胃肠道线虫感染的研究。

体外研究

Pyrantel induces Ascaris suum muscle contraction, with a pEC 50 of 7.24. Pyrantel produces spastic paralysis of the nematode by selectively gating acetylcholine receptor ion-channels on nerve and muscle. Pyrantel (72 h) inhibits the survival of Ancylostoma ceylanicum , Necator americanus and Trichuris muris on the third-stage larvae (IC 50 s=90.9, 2.0, and 95.5 µg/mL, respectively) and adult worms (IC 50 s=>100, 7.6, and 34.1 µg/mL, respectively).

体内研究

Pyrantel (10 mg/kg; a single p.o.) reduces the worms in A. ceylanicum -infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%.

危险品标志 

T

危险类别码 

25

安全说明 

45

危险品运输编号 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS号

UW0249000

HazardClass 

6.1(b)

PackingGroup 

III

海关编码 

2934990002