异茴芹灵

中文名称:

异茴芹灵

中文同义词:

异茴芹灵;异茴芹内酯(异茴芹灵;异虎耳草素、异茴芹灵、异茴芹内酯;异茴芹内酯(标准品);异茴芹内酯(异茴芹灵,异虎耳草素,茴芹香豆素,异茴芹素);ISOPIMPINELLIN 异茴芹内酯;异茴芹灵,异虎耳草素;异茴芹内酯

英文名称:

ISOPIMPINELLIN

英文同义词:

4,9-Dimethoxy-7H-furo[3,2-g]chromen-7-one;4,9-Dimethoxy-furo[3,2-g]chromen-7-one;5,8-Dimethoxy-6,7-furanocoumarin;5,8-Dimethoxypsoralen;5,8-Dimethoxypsoralene;7H-Furo[3,2-g][1]benzopyran-7-one, 4,9-dimethoxy-;7H-Furo[3,2-g][1]benzopyran-7-one,4,9-dimethoxy-;ISOPIMPINELLIN

CAS号:

482-27-9

分子式:

C13H10O5

分子量:

246.22

EINECS号:

相关类别:

中草药成分;中药标准品;中药对照品;标准品;对照品,标准品;分析标准品;植物提取物;Coumarins;Heterocyclic Compounds;Heterocycles;对照品;植提标准品;对照品-中药对照品;木脂素;标准品 -中药标准品;分析试剂-标准品;标准品，对照品

Mol文件:

482-27-9.mol

熔点 

150-151°C

沸点 

448.7±45.0 °C(Predicted)

密度 

1.352±0.06 g/cm3(Predicted)

储存条件 

Sealed in dry,2-8°C

最大波长(λmax)

268nm(MeOH)(lit.)

BRN 

262337

CAS 数据库

482-27-9(CAS DataBase Reference)

生物活性

Isopimpinellin 是从Pimpinella saxifrage 根部分离得到的一种具有口服活性的化合物。Isopimpinellin 通过7,12-dimethylbenz[a]anthracene.阻断 DNA加合物的形成和皮肤肿瘤的发生。Isopimpinellin 具有抗利什曼病的活性。

体内研究

Isopimpinellin (oral gavage, 35-150 mg/kg) inhibits B[a]P-DNA adduct formation and DMBA–DNA adduct formation in SENCAR mice with skin tumor. Animal Model: Female SENCAR mice (7-9 weeks of age) were fed AIN-76A semi-purified diet (Dyets, Bethlehem, PA) for 2 weeks prior to and during the study. Dosage: 35–150 mg/kg. Administration: Oral gavage, suspended in 0.1 mL corn oil at 24 h and 2 h prior to topical treatment with [3H]B[a]P (200 nmol, 1 Ci/mmol) or [3H]DMBA (10 nmol, 10 Ci/mmol) (each in 0.2 mL acetone). Result: Significantly inhibited B[a]P-DNA adduct formation by 37 and 26%, respectively. Isopimpinellin (35, 70 and 150 mg/kg) blocked DMBA–DNA adduct formation by 23, 56 and 69%, respectively

Animal Model:

Female SENCAR mice (7-9 weeks of age) were fed AIN-76A semi-purified diet (Dyets, Bethlehem, PA) for 2 weeks prior to and during the study.

Dosage:

35–150 mg/kg.

Administration:

Oral gavage, suspended in 0.1 mL corn oil at 24 h and 2 h prior to topical treatment with [3H]B[a]P (200 nmol, 1 Ci/mmol) or [3H]DMBA (10 nmol, 10 Ci/mmol) (each in 0.2 mL acetone).

Result:

Significantly inhibited B[a]P-DNA adduct formation by 37 and 26%, respectively. Isopimpinellin (35, 70 and 150 mg/kg) blocked DMBA–DNA adduct formation by 23, 56 and 69%, respectively

化学性质 

淡黄色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于虎耳草，蛇床子。

用途 

用于含量测定/鉴定/药理实验等

用途 

用作中药对照品

危险品标志 

T+

危险类别码 

20/21/22-28

安全说明 

22-36/37/39-45-36/37-28

危险品运输编号 

UN 2811 6.1 / PGII

WGK Germany 

3

RTECS号

LV1049200

海关编码 

2932202000