异长叶烯

中文名称:

异长叶烯

中文同义词:

(-)-异长叶烯;异长叶烯;(2S)-1,3,4,5,6,7-六氢-1,1,5,5-四甲基-2H-2,4A-亚甲基萘;(1R)-2,2,7,7-四甲基三环[6.2.1.01.6]十一-5-烯;异长叶烯(甄准不供应)

英文名称:

Isolongifolene

英文同义词:

(-)-Isolongifolene >=98.0% (suM of enantioMers, GC);(-)-Isolongifoline;(2s)-1,3,4,5,6,7-hexahydro-1,1,5,5;(2s)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2h-2,4a-methanonaphthalene;2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-;C15 H24, 2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S)-;ISOLONGIFOLENE(SG);(2s)-2h-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-4a-methanonaphthalen

CAS号:

1135-66-6

分子式:

C15H24

分子量:

204.35

EINECS号:

214-494-2

相关类别:

标准品;香精香料;植物提取物;原料;香精与香料咨询13026126800;有机化工原料;其他原料

Mol文件:

1135-66-6.mol

沸点 

255-256 °C

密度 

0.930 g/mL at 20 °C(lit.)

折射率 

n20/D 1.499

闪点 

49°C

储存条件 

2-8°C

旋光性 (optical activity)

[α]20/D 138±2°, c = 1% in ethanol

BRN 

2207559

CAS 数据库

1135-66-6(CAS DataBase Reference)

NIST化学物质信息

2H-2,4a-methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2s)-(1135-66-6)

EPA化学物质信息

2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S,4aR)- (1135-66-6)

生物活性

Isolongifolene ((-)-Isolongifolene) 是一种从 Murraya koenigii 中分离的三环倍半萜烯。Isolongifolene 通过调节 P13K/AKT/GSK-3β 信号通路来减轻鱼藤酮诱导的氧化应激，线粒体功能障碍和细胞凋亡。Isolongifolene 具有抗氧化，抗炎，抗癌和神经保护的特性。

体外研究

Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene. Cell Viability Assay Cell Line: SH-SY5Y neuroblastoma cells Concentration: 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 µM Incubation Time: 26 hours Result: Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells. Apoptosis Analysis Cell Line: SH-SY5Y neuroblastoma cells Concentration: 10 µM Incubation Time: 26 hours Result: Attenuated Rotenone-induced apoptosis in SH-SY5Y cells. Western Blot Analysis Cell Line: SH-SY5Y neuroblastoma cells Concentration: 10 µM Incubation Time: 26 hours Result: Attenuated rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.

Cell Line:

SH-SY5Y neuroblastoma cells

Concentration:

0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 µM

Incubation Time:

26 hours

Result:

Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells.

Cell Line:

SH-SY5Y neuroblastoma cells

Concentration:

10 µM

Incubation Time:

26 hours

Result:

Attenuated Rotenone-induced apoptosis in SH-SY5Y cells.

Cell Line:

SH-SY5Y neuroblastoma cells

Concentration:

10 µM

Incubation Time:

26 hours

Result:

Attenuated rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.

用途 

是制造具有木香香气的合成香料异长叶烷酮和异长叶甲酸酯的主要原料

危险类别码 

10

危险品运输编号 

UN 2319 3/PG 3

WGK Germany 

3

HazardClass 

3.2

PackingGroup 

III