苦番紅花素

中文名称:

苦番紅花素

中文同义词:

苦番花素;苦番红花素;苦藏花素;苦番紅花素;藏红花苦甙

英文名称:

Picrocrocin

英文同义词:

Picrocrocin;(R)-4-(β-D-glucopyranosiloxy)-2,6,6-trimethyl-1-cyclohexene-1-carbaldehyde;(R)-4-(β-D-Glucopyranosyloxy)-2,6,6-trimethyl-1-cyclohexene-1-carbaldehyde;Saffron-bitter;Picrocrocine;1-Cyclohexene-1-carboxaldehyde,4-(b-D-glucopyranosyloxy)-2,6,6-triMethyl-,(4R)-;Safranbitter;(4S)-2,6,6-trimethyl-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-cyclohexene-1-carbaldehyde

CAS号:

138-55-6

分子式:

C16H26O7

分子量:

330.37

EINECS号:

相关类别:

中草药成分;分析试剂标准品;对照品;标准品-对照品;对照品;标准品，对照品;20版药典新增

Mol文件:

138-55-6.mol

熔点 

196℃ (ethyl acetate )

比旋光度 

D20 -58° (c = 0.6)

沸点 

520.4±50.0 °C(Predicted)

密度 

1.31±0.1 g/cm3 (20 ºC 760 Torr)

酸度系数(pKa)

12.91±0.70(Predicted)

生物活性

Picrocrocin，一种发现于椰菜花中的类胡萝卜素。Picrocrocin 具有抗癌作用。Picrocrocin 对 SKMEL-2 人恶性黑色素瘤细胞具有生长抑制作用。

体外研究

Picrocrocin exerted growth inhibitory effects on the SK-MEL-2 melanoma cells. The IC 50 of picrocrocin against the SK-MEL-2 cells was 20 μM at 24-h incubation. The antiproliferative activity of picrocrocin was due to apoptosis and cell cycle arrest. In addition, picrocrocin enhanced the ROS levels and decreased the MMP levels of SK-MEL-2 cells. Finally, picrocrocin inhibited the JAK/STAT5 signalling pathway in the SK-MEL-2 melanoma cells.