AKT 激酶抑制剂

中文名称:

AKT 激酶抑制剂

中文同义词:

AKT 激酶抑制剂;AKT抑制剂(AKT KINASE INHIBITOR)

英文名称:

AKT Kinase Inhibitor

英文同义词:

AKT Kinase Inhibitor;3-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-propyn-1-ol;2-Propyn-1-ol, 3-[2-(4-aMino-1,2,5-oxadiazol-3-yl)-7-(3-aMinopropoxy)-1-ethyl-1H-iMidazo[4,5-c]pyridin-4-yl]-;AKT Kinase Inhibitor (2-Propyn-1-ol, 3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-);3-[2-(4-amino-1;5-c]pyridin-4-yl]-;5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4;AKT Kinase Inhibitor USP/EP/BP

CAS号:

842148-40-7

分子式:

C16H19N7O3

分子量:

357.37

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

842148-40-7.mol

密度 

1.50

生物活性

AKT Kinase Inhibitor 是一种具有抗肿瘤活性的 Akt 抑制剂。

靶点

Akt

Akt

体外研究

The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion.

体内研究

Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus.