2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺

中文名称:

2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺

中文同义词:

2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺;FH535, 一种WNT/Β-CATENIN和PPAR信号传导抑制剂;WNT/BETA-CATENIN和PPAR信号通路抑制剂(FH535)

英文名称:

FH 535

英文同义词:

β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem;CS-1433;FH 535;N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonaMide;2,5-Dichloro-N-(2-Methyl-4-nitrophenyl)benzenesulfonaMide;2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide FH535;β-Catenin/Tcf Inhibitor, FH535;FH 535(FH-535)

CAS号:

108409-83-2

分子式:

C13H10Cl2N2O4S

分子量:

361.2

EINECS号:

相关类别:

细胞生物学试剂;小分子抑制剂;小分子抑制剂，天然产物;API;Aromatics;Inhibitors;Intermediates Fine Chemicals;Pharmaceuticals

Mol文件:

108409-83-2.mol

熔点 

141-142℃

沸点 

526.3±60.0 °C(Predicted)

密度 

1.566±0.06 g/cm3(Predicted)

储存条件 

2-8°C

溶解度 

DMSO: soluble20mg/mL

酸度系数(pKa)

5.83±0.10(Predicted)

形态

Yellow solid

InChIKey

AXNUEXXEQGQWPA-UHFFFAOYSA-N

生物活性

FH535 是 Wnt/β-catenin 和 PPAR 的抑制剂，具有抗肿瘤活性。

靶点

PPAR Wnt β-catenin

PPAR

Wnt

体外研究

FH535 is an inhibitor of Wnt/β-catenin and PPAR. FH535 inhibits PPARγ and PPARδ transactivation in HCT116 cells. FH535 (15 μM) activities depend on functional PPARδ but does not require a cysteine residue in the PPAR ligand-binding domain. FH535 inhibits recruitment of the coactivators GRIP1 and β-catenin to PPARδ and PPARγ. FH535 shows toxic effects on 12 carcinoma cell lines expressing wnt/β-catenin pathway. FH535 (20 μM) suppresses the β-catenin pathway in pancreatic cancer cells, and inhibits pancreatic cancer cell migration. Furthermore, FH535 (20, 40 μM) inhibits pancreatic cancer cell invasion and cell growth. FH535 represses angiogenesis-related genes in pancreatic cancer cells.

体内研究

FH535 (25 mg/kg, i.p.) exhibits an anti-tumor effect on pancreatic cancer xenografts in mice. FH535 also represses angiogenesis in pancreatic cancer xenografts.

危险品标志 

Xi

危险类别码 

41

安全说明 

36

WGK Germany 

3

海关编码 

29350090