安五脂素

中文名称:

安五脂素

中文同义词:

安五脂素 (安五酯素);ANWULIGAN 安五酯素;安五脂素, 来源于五味子;安五酯素;安五脂素;安五脂素, >98%;安五脂素标准品;安五脂素对照品

英文名称:

Anwuligan

英文同义词:

Anwuligan;4-[(2S,3R)-4-(1,3-Benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxyphenol;Macelignan;Phenol,4-[(2S,3R)-4-(1,3-benzodioxol-5-yl)-2,3-diMethylbutyl]-2-Methoxy-;Calophyn;ANWULIGNAN;Anwuligan, 98%, from Schisandra chinensis;4-(2S,3R)-4-(1,3-benzodioxol-5-yl-2-3-dimetybty]-2_methoxyphenol

CAS号:

107534-93-0

分子式:

C20H24O4

分子量:

328.4

EINECS号:

相关类别:

分析试剂标准品;中药对照品;标准品;植物提取物;对照品;对照品-中药对照品;木脂素;标准品 -中药标准品;标准品，对照品

Mol文件:

107534-93-0.mol

熔点 

70-71℃

沸点 

467.0±40.0 °C(Predicted)

密度 

1.159

闪点 

236℃

酸度系数(pKa)

10.19±0.20(Predicted)

生物活性

Macelignan ((+)-Anwulignan; Anwuligan) 是一种从肉豆蔻中分离得到的生物活性木脂素 (lignan)。Macelignan 具有多种药理活性，包括抗炎、抗癌、抗糖尿病和神经保护活性。

靶点

COX-2

COX-2

体外研究

Macelignan (1-50 μM; 72 hours) does not reduce cell viability alone, however, UVB treatment, even at the lowest dose of 30 mJ/cm 2 , reduces HaCaT cell viability in a dose-dependent mannner,it reduces approximately 80% of control values at 100 μM in hacat cells.Macelignan (0.1-1 μM; 24 hours) decreases COX-2 expression in a concentration-dependent manner,and at the highest concentration of macelignan (1 μM) , COX-2 expression is inhibited by almost 50% in hacat cells. Cell Viability Assay Cell Line: Hacat cells Concentration: 1 μM; 2.5 μM; 5 μM; 10 μM; 15 μM; 50 μM Incubation Time: 72 hours Result: Induced cell death by UVB irradiation at 30 mJ/cm 2 from 10 μM. Western Blot Analysis Cell Line: Hacat cells Concentration: 0.1 μM; 0.5 μM;1 μM Incubation Time: 24 hours Result: Reduced UVB-induced COX-2 expression in cells.

Cell Line:

Hacat cells

Concentration:

1 μM; 2.5 μM; 5 μM; 10 μM; 15 μM; 50 μM

Incubation Time:

72 hours

Result:

Induced cell death by UVB irradiation at 30 mJ/cm 2 from 10 μM.

Cell Line:

Hacat cells

Concentration:

0.1 μM; 0.5 μM;1 μM

Incubation Time:

24 hours

Result:

Reduced UVB-induced COX-2 expression in cells.

体内研究

Macelignan (oral administration; 15 mg/kg; every day for three weeks) exhibits in vivo anti-diabetic effects. The baseline (day 0) fasting blood glucose levels does not differ between groups; at the end of the experiment, the values of the Macelignan-treated group are significantly lower compared to the diabetic control group in C57BL/KsJ- db/db mice. Animal Model: Male C57BL/KsJ- db/db mice Dosage: 15 mg/kg Administration: Oral administration; 15 mg/kg; every day for three weeks Result: Significantly reduced the blood glucose levels in mice.

Animal Model:

Male C57BL/KsJ- db/db mice

Dosage:

15 mg/kg

Administration:

Oral administration; 15 mg/kg; every day for three weeks

Result:

Significantly reduced the blood glucose levels in mice.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于五味子Schisandra chinensis 的根或皮。

用途 

安五脂素有抗肿瘤、凝血的作用。

用途 

用于含量测定/鉴定/药理实验等 药理药效:抗肿瘤、凝血

海关编码 

29329990