育亨宾碱

中文名称:

育亨宾碱

中文同义词:

洛芙素盐酸盐;ALPHA-盐酸育亨宾;萝芙素盐酸盐;育亨宾盐酸盐, 来源于育亨宾;育亨宾碱;育亨宾提取物 育亨宾碱;萝芙素;萝芙素盐酸盐(甄准不供应)

英文名称:

RAUWOLSCINE HYDROCHLORIDE

英文同义词:

RAUWOLSCINE HYDROCHLORIDE (A-YOHIMBINE) A2 AD;α-Yohimbine hydrochloride, 17α-Hydroxy-20α-yohimban-16 β-carboxylic acid methyl ester hydrochloride;Corynanthidine hydrochloride;Isoyohimbine hydrochloride;Rauwolscine dot hydrochloride;ALPHA YOHIMBINE HCL 90% (Rauwolscine HCL 90%);YohiMban-16-carboxylicacid, 17-hydroxy-, Methyl ester, hydrochloride (1:1), (16b,17a,20a)-;YOHIMBINE HCL, ALPHA-

CAS号:

6211-32-1

分子式:

C21H27ClN2O3

分子量:

390.9

EINECS号:

228-279-6

相关类别:

植物提取物;原料;Adrenoceptor

Mol文件:

6211-32-1.mol

熔点 

270-280°C

储存条件 

Store at RT

溶解度 

H2O: soluble

形态

solid

颜色

white

敏感性 

Light Sensitive

生物活性

Rauwolscine hydrochloride是高效，选择性的 α2 adrenergic 受体拮抗剂，Ki 值为12 nM。

靶点

Target Value α2 adrenergic receptor () 12 nM(Ki)

Target

Value

α2 adrenergic receptor ()

12 nM(Ki)

体外研究

[ 3 H]Rauwolscine binding to α2 adrenergic receptor is reversible, stcreospccific, and saturable. [ 3 H]Rauwolscine specifically labels both the high and low affinity states of the α2 adrenergic receptor in brain membranes. [ 3 H]Rauwolscine also behaves as a 5-HT1A receptor agonist and this conclusion is compatible with earlier functional studies, indicating that rauwolscine (as well as yohimbine) has agonistic properties at the level of 5-HT autoreceptors. When using [ 3 H]5-HT as a radioligand, rauwolscine is determined to have relatively high affinity for the human receptor (K i human=14.3 nM, K i rat=35.8 nM). Saturation studies shows that the affinity of [ 3 H]Rauwolscine is similar in mouse, rat, rabbit, dog (2.33-3.03 nM) except man where it is significantly higher (0.98 nM) .

危险品标志 

T

危险类别码 

23/24/25

安全说明 

22-36/37/39-45

危险品运输编号 

UN 1544 6.1/PG 2

WGK Germany 

3

RTECS号

ZG1035000

HazardClass 

6.1

海关编码 

29339900