莪术呋喃烯

中文名称:

莪术呋喃烯

中文同义词:

莪术烯;CURZERENE 莪术烯;莪术烯莪术烯;莪术呋喃烯;莪术烯(黄色油状液体);莪术烯标准品;莪术烯对照品

英文名称:

Curzerene

英文同义词:

Curzerene;Isofuranogermacrene;Isogermafurene;Isogermafuren;Neocurzerene;Benzofuran, 6-ethenyl-4,5,6,7-tetrahydro-3,6-dimethyl-5-(1-methylethenyl)-, (5R,6R)-rel-

CAS号:

17910-09-7

分子式:

C15H20O

分子量:

216.32

EINECS号:

相关类别:

中药对照品;标准品;对照品,标准品;对照品;植物提取物;对照品-中药对照品;标准品 -中药标准品;标准品，对照品;化工原料

Mol文件:

17910-09-7.mol

沸点 

282.8±40.0℃ (760 Torr)

密度 

0.982±0.06 g/cm3 (20 ºC 760 Torr)

闪点 

117.5±14.2℃

概述

莪术呋喃烯是一种有机杂环化合物，具有抗肿瘤作用，可以制备药物组合物。

生物活性

Curzerene 是倍半萜，从 Curculigo orchioides Gaertn 的根茎中分离出来的，具有抗癌活性。 Curzerene 抑制谷胱甘肽 S-转移酶 A1 (GSTA1) mRNA 和蛋白表达。Curzerene 诱导细胞凋亡 (apoptosis)。

靶点

GSTA1

体外研究

Curzerene (0-100 µM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC 50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 µM, and 47.01 µM, respectively. Curzerene (0-100 µM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells. Curzerene(0-100 µM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose. Curzerene (6.25-100 µM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells. Curzerene (6.25-100 µM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells. Cell Viability Assay Cell Line: SPC-A1 cells Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM Incubation Time: 24 hours, 48 hours, 72 hours Result: Inhibited growth of non-small cell lung cancer SPC A1 cells in vitro. Apoptosis Analysis Cell Line: SPC-A1 cells Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM Incubation Time: 48 hours Result: Induced apoptosis of the cells in a dose-dependent manner. Apoptosis Analysis Cell Line: SPC-A1 cells Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM Incubation Time: 48 hours Result: Induced G2/M cell cycle arrest of SPC A1 cells. RT-PCR Cell Line: SPC-A1 cells Concentration: 6.25 µM, 25 µM, 100 µM Incubation Time: 48 hours Result: Decreased GSTA1 mRNA expression.

Cell Line:

SPC-A1 cells

Concentration:

0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM

Incubation Time:

24 hours, 48 hours, 72 hours

Result:

Inhibited growth of non-small cell lung cancer SPC A1 cells in vitro.

Cell Line:

SPC-A1 cells

Concentration:

0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM

Incubation Time:

48 hours

Result:

Induced apoptosis of the cells in a dose-dependent manner.

Cell Line:

SPC-A1 cells

Concentration:

0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM

Incubation Time:

48 hours

Result:

Induced G2/M cell cycle arrest of SPC A1 cells.

Cell Line:

SPC-A1 cells

Concentration:

6.25 µM, 25 µM, 100 µM

Incubation Time:

48 hours

Result:

Decreased GSTA1 mRNA expression.

化学性质 

无色晶体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于莪术。

用途 

莪术烯具有行气破血，消积止痛。用于燀瘕痞块，瘀血经闭，食积胀痛；早期宫颈癌的作用。