远志酸

中文名称:

远志酸

中文同义词:

毛果一枝黄花皂苷元G;远志酸, 来源于远志;远志酸(标准品);远志酸;远志酸,毛果一枝黄花皂苷元G

英文名称:

Polygalacic acid

英文同义词:

Polygalacic acid;Polygalacic;(2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid;Olean-12-en-28-oicacid, 2,3,16,23-tetrahydroxy-, (2β,3β,4,16)-;Virgaureagenin G;(4R)-2β,3β,16α,23-Tetrahydroxyolean-12-en-28-oic acid;Polygalacic acid or (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid;Polygalacic acid (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid

CAS号:

22338-71-2

分子式:

C30H48O6

分子量:

504.7

EINECS号:

相关类别:

中药对照品;标准品;分析标准品;植物提取物;植提标准品;中药标准品;对照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-对照品;标准品，对照品;标准品-中药标准品

Mol文件:

22338-71-2.mol

熔点 

300-305 °C (sublm)

沸点 

638.1±55.0 °C(Predicted)

密度 

1.23±0.1 g/cm3(Predicted)

酸度系数(pKa)

4.41±0.70(Predicted)

生物活性

Polygalacic acid 是从远志属植物（Polygala paenea L.）分离出的三萜类四羟酸。Polygalacic acid (0-100μM; 24h) 可以显著降低 MMP-3、MMP-9、MMP-13 和 COX-2 的mRNA表达，这些因子的表达由IL-1β诱导可显著增加，并呈现出剂量依赖性。

体外研究

Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid. RT-PCR Cell Line: Chondrocyte cells Concentration: 50 μM; 100 μM Incubation Time: 24 hours Result: Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression. Western Blot Analysis Cell Line: Chondrocyte cells Concentration: 50 μM; 100 μM Incubation Time: 6 hours Result: Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes.

Cell Line:

Chondrocyte cells

Concentration:

50 μM; 100 μM

Incubation Time:

24 hours

Result:

Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression.

Cell Line:

Chondrocyte cells

Concentration:

50 μM; 100 μM

Incubation Time:

6 hours

Result:

Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes.

用途 

安神，祛痰，消肿等，临床多用于治疗支气管炎和引产，催产等。

海关编码 

29163990