5-((2R,3R)-2,3-二氢-7-甲氧基-3-甲基-5-(1E)-1-丙烯基-2-苯并呋喃基)-1,3-苯并二氧杂

中文名称:

5-((2R,3R)-2,3-二氢-7-甲氧基-3-甲基-5-(1E)-1-丙烯基-2-苯并呋喃基)-1,3-苯并二氧杂环戊烯

中文同义词:

利卡灵-B(利卡灵B);(-)-LICARIN B 利卡灵-B;5-((2R,3R)-2,3-二氢-7-甲氧基-3-甲基-5-(1E)-1-丙烯基-2-苯并呋喃基)-1,3-苯并二氧杂环戊烯;利卡灵-B;利卡灵-B(标准品);(-)-利卡灵B;利卡灵B对照品,

英文名称:

licarin B

英文同义词:

1,3-Benzodioxole,5-[(2R,3R)-2,3-dihydro-7-Methoxy-3-Methyl-5-(1E)-1-propenyl-2-benzofuranyl]-(9CI);licarin B;5-[(2S)-2,3-Dihydro-7-methoxy-3β-methyl-5-[(E)-1-propenyl]benzofuran-2-yl]-1,3-benzodioxole;5-((2R,3R)-2,3-Dihydro-7-methoxy-3-methyl-5-(1E)-1-propenyl-2-benzofuranyl)-1,3-benzodioxole;5-[(3S)-7-methoxy-3-methyl-5-[(E)-prop-1-enyl]-2,3-dihydro-1-benzofuran-2-yl]-1,3-benzodioxole;Licarine B;1,3-Benzodioxole, 5-[(2R,3R)-2,3-dihydro-7-methoxy-3-methyl-5-(1E)-1-propen-1-yl-2-benzofuranyl]-;(-)-Licarin B

CAS号:

51020-87-2

分子式:

C20H20O4

分子量:

324.37

EINECS号:

2017-001-1

相关类别:

分析试剂标准品;对照品;植提标准品;中药对照品;标准品;植物提取物;标准品-中药标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;reagent;standard substance;标准品-对照品;标准品 -中药标准品;标准品，对照品

Mol文件:

51020-87-2.mol

沸点 

428.5±45.0 °C(Predicted)

密度 

1.201±0.06 g/cm3(Predicted)

储存条件 

Sealed in dry,2-8°C

生物活性

Licarin B 可来源于 Myristica fragrans 的种子，是 NO 生成的抑制剂，可通过激活 IRS-1/PI3K/AKT 通路中的 PPARγ 和GLUT4 改善胰岛素敏感性。

靶点

PPARγ GLUT4

PPARγ

GLUT4

体外研究

Licarin B (5 μM, 10 μM, 15 μM. 8 days) moderately increases TG accumulation during adipogenic differentiation and showed partial PPARg agonist activity in 3T3-L1 preadipocytes. Cell Viability Assay Cell Line: 3T3-L1 cell. Concentration: 1-500 μM. Incubation Time: 48 h. Result: Did not cause significant cell death up to 500 μM concentration. Cell Viability Assay Cell Line: 3T3-L1 cell. Concentration: 5 μM, 10 μM, 15 μM. Incubation Time: 8 days (replaced every 2 days). Result: LB at 15 μM concentration significantly promoted adipocyte differentiation and caused intracellular TG accumulation.

Cell Line:

3T3-L1 cell.

Concentration:

1-500 μM.

Incubation Time:

48 h.

Result:

Did not cause significant cell death up to 500 μM concentration.

Cell Line:

3T3-L1 cell.

Concentration:

5 μM, 10 μM, 15 μM.

Incubation Time:

8 days (replaced every 2 days).

Result:

LB at 15 μM concentration significantly promoted adipocyte differentiation and caused intracellular TG accumulation.

化学性质 

白色结晶，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于肉豆蔻， 樟科(Lauraceae) 李卡樟 Licarin aritu Ducke 树干(收率:0.35%) 日本润楠 Machilus japonica Sieb.et Zucc.叶红楠 Machilus thunbergii Sieb.et Zucc.树皮,木材,叶。

用途 

利卡灵-B具有抗菌、消炎、镇静、抗肿瘤的作用。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:现代药理学研究表明，肉豆蔻具有抗菌、消炎、镇静、抗肿瘤等作用。