人参皂苷 RK3

中文名称:

人参皂苷 RK3

中文同义词:

人参皂苷 RK3;人参皂苷RK3,R1=葡萄糖;人参皂甙RK3;人参皂苷RK3(人参皂甙RK3);人参皂苷RK3(标准品);人参皂苷RK3对照品

英文名称:

Ginsenoside Rk3

英文同义词:

Ginsenoside Rk3;Ginsenoside Rk3 standard;β-D-Glucopyranoside, (3β,6α,12β)-3,12-dihydroxydammara-20,24-dien-6-yl

CAS号:

364779-15-7

分子式:

C36H60O8

分子量:

620.87

EINECS号:

相关类别:

植物提取物;中药对照品;植提标准品;对照品;标准品;分析试剂标准品;标准品-对照品;对照品-中药对照品;标准品 -中药标准品;标准品，对照品

Mol文件:

364779-15-7.mol

沸点 

722.4±60.0 °C(Predicted)

密度 

1.20±0.1 g/cm3 (20 ºC 760 Torr)

酸度系数(pKa)

12.91±0.70(Predicted)

生物活性

Ginsenoside Rk3 存在于 Panax notoginseng 的根中。在 HepG2 细胞中 Ginsenoside Rk3 抑制 TNF-α 诱导的 NF-κB 转录活性， IC50 值为 14.24±1.30 μM。

靶点

NF-κB 14.24 μM (IC 50 , in HepG2 cells) NF-κB 15.32 μM (IC 50 , in SK-Hep1 cell)

NF-κB 14.24 μM (IC 50 , in HepG2 cells)

NF-κB 15.32 μM (IC 50 , in SK-Hep1 cell)

体外研究

Ginsenoside Rk3 exerts the strong activity inhibiting NF-κB in a dose-dependent manner. HepG2 cells are pre-treated with different ginsenosides at concentrations ranging from 0.01 to 10 μM for 1 h, and induced with TNF-α for 20 h. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC 50 of 14.24±1.30 μM. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC 50 of 15.32±0.29 μM in SK-Hep1 cells, consistent with the data from HepG2 cells. Consistent with the inhibition of NF-κB, Ginsenoside Rk3 inhibits the induction of IL8 , CXCL1 , iNOS , and ICAM1 mRNA significantly in a dose-dependent manner.

体内研究

The inhibitory effects of Ginsenoside Rk3 (Rk3) on tumor progression are studied in vivo using a H460 xenograft model in nude mice. Compared with the control group, a significant inhibition of tumor growth (volume) is observed in the Ginsenoside Rk3-treated group. Twenty-one days after treatment initiation, tumor growth is significantly inhibited by approximately 62.99% in the mice receiving 20 mg/kg Ginsenoside Rk3, similar to the inhibitory effect observed in the 20 mg/kg Gefitinib-treated group (57.21%). Compared with the control group, tumor growth is moderately inhibited in the mice receiving 10 and 5 mg/kg Ginsenoside Rk3, with inhibition rates of 32.54% and 11.84%, respectively.

化学性质 

白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:可能有心血管、按肿瘤方面的活性

用途 

人参皂苷RK3存在于加工的田三七中，是常用的缺血性心脏疾病的复方制剂的主要成分。