人参皂苷RO

中文名称:

人参皂苷RO

中文同义词:

人参皂苷RO;竹节参皂苷V;竹节参苷V;人参皂苷RO(标准品);人参皂苷RO、 竹节参苷V;人参皂苷RO(分析标准品);人参皂苷RO/竹节参苷V 标准品;人参皂苷RO对照品,

英文名称:

GinsenosideRo

英文同义词:

(3beta)-28-(beta-D-Glucopyranosyloxy)-28-oxoolean-12-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranosiduronic acid;Chikusetsusaponin 5;ChikusetsusaponinV;PolysciasaponinP3;β-D-Glucopyranosiduronic acid, (3β)-28-(β-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl2-O-β-D-glucopyranosyl-;28-(β-D-Glucopyranosyloxy)-28-oxo-5α-olean-12-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranosiduronic acid;28-(β-D-Glucopyranosyloxy)-28-oxoolean-12-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranosiduronic acid;3β-(2-O-β-D-Glucopyranosyl-β-D-glucopyranuronosyloxy)oleana-12-ene-28-oic acid 28-β-D-glucopyranosyl ester

CAS号:

34367-04-9

分子式:

C48H76O19

分子量:

957.11

EINECS号:

相关类别:

分析试剂标准品;对照品;人参皂苷系列;中药对照品;标准品;对照品,标准品;植物提取物;The group of Ginsenosides;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;植提标准品;标准品-中药标准品;标准品 -中药标准品;三萜;分析试剂-对照品;标准品，对照品;20版药典新增

Mol文件:

34367-04-9.mol

沸点 

1018.6±65.0 °C(Predicted)

密度 

1.14

酸度系数(pKa)

2.76±0.70(Predicted)

生物活性

Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V) 具有 Ca2+ 拮抗剂的抗血小板作用，IC50 为 155  μM。Ginsenoside Ro 降低 TXA2 产量，Ginsenoside Ro 还稍弱地降低 COX-1 和 TXAS 活性。

靶点

TXA 2 Ca 2+

TXA 2

Ca 2+

体外研究

Ginsenoside Ro in Panax ginseng is a beneficial novel Ca 2+ -antagonistic compound and may prevent platelet aggregation-mediated thrombotic disease. Ginsenoside Ro dose-dependently reduces thrombin-stimulated platelet aggregation, and IC 50 is approximately 155 μM. Ginsenoside Ro inhibits TXA 2 production to abolish thrombin-induced platelet aggregation. Thromboxane A 2 (TXA 2 ) induces platelet aggregation and promotes thrombus formation. Ginsenoside Ro dose-dependently (50-300 μM) reduces the TXB 2 level that is induced by thrombin; Ginsenoside Ro (300 μM) inhibits the thrombin-mediated elevation in TXB 2 level by 94.9%. COX-1 activity in the absence of Ginsenoside Ro (negative control) is 2.3±0.1 nmol/mg protein. However, Ginsenoside Ro dose-dependently (50-300 μM) reduces its activity; at 300 μM, COX-1 activity is reduced by 26.4% of that of the negative control. TXA 2 synthase (TXAS) activity in the absence of Ginsenoside Ro (negative control) is 220.8±1.8 ng/mg protein/min. However, Ginsenoside Ro dose-dependently (50-300 μM) reduces its activity; at 300 μM, TXAS activity is reduced by 22.9% of that of the negative control. The inhibitory effect of Ginsenoside Ro (300 μM) on TXB 2 production (94.9%) is significantly higher than those on COX-1 (26.4%) and TXAS (22.9%) activities. To assess the toxicity of Ginsenoside Ro in Raw 264.7 cells, they are first treated with various concentrations (10 μM, 50 μM, 100 μM, and 200 μM) of Ginsenoside Ro for 24 h. Ginsenoside Ro exhibits no significant dose dependent toxicity. The effect of Ginsenoside Ro is next determined on cell viability and ROS levels, a marker of oxidative stress, following treatment with 1 μg/mL LPS. LPS reduces cell viability by ∼70% compared with nontreated controls. Pretreatment with 100 μM and 200 μM Ginsenoside Ro for 1 h prior to 1 μg/mL LPS incubation for 24 h leads to a significant increase in cell viability. The changes in ROS levels and NO production are consistent with the effects of Ginsenoside Ro on viability.

体内研究

Ginsenoside Ro dissolved in water is administrated by gavage to mice at doses of 25 and 250 mg/kg/day for 4 days before i.v. injection of HT29 in order to keep blood concentrations of Ginsenoside Ro above a certain level before HT29 i.v. injection followed by 40 days of oral administration of Ginsenoside Ro to the mice. After 38 days of treatment, the animals are euthanized, and the number of pulmonary metastatic nodules is counted in addition to evaluation of toxicity of Ginsenoside Ro and mouse pathology by HT29. Ginsenoside Ro (250 mg/kg/day) produces a significant decrease in the number of tumor nodules on the lung surface, yielding inhibition rates of 88% (P [4] .

化学性质 

白色粉末，易溶于甲醇乙醇，来源于人参。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:人参主要具有大补元气，滋补强壮，安神益智，生津，复脉固脱等功效。

用途 

人参皂苷Ro是人参根茎的主要皂苷成分，有抗炎症、抗肝炎等生物活性。

海关编码 

29389090