桑皮苷A

中文名称:

桑皮苷A

中文同义词:

桑皮苷A;桑皮苷A(标准品);MULBERROSIDE A 桑皮苷A;桑皮苷A(分析标准品);桑皮苷A, 来源于桑树;桑皮苷A对照品,

英文名称:

mulberroside A

英文同义词:

mulberroside A;2,5-Dihydroxy-4,3-bis(beta-D-glucopyranosyloxy)-trans-stilbene;beta-D-Glucopyranoside 3-[(1E)-2-[4-(beta-D-glucopyranosyloxy)-2-hydroxyphenyl]ethenyl]-5-hydroxyphenyl;2,5-Dihydroxy-4,3-bis(β-D-glucopyranosyloxy)-trans-stilbene;Mulberroside A, 98%, from Morus alba L.;2-(4-hydroxy-1,3-thiazol-3-ium-3-yl)ethyl [2-(octadecylcarbamoyloxymethyl)oxolan-2-yl]methyl phosphate;β-D-Glucopyranoside, 3-[(1E)-2-[4-(β-D-glucopyranosyloxy)-2-hydroxyphenyl]ethenyl]-5-hydroxyphenyl;b-D-Glucopyranoside,3-[(1E)-2-[4-(b-D-glucopyranosyloxy)-2-hydroxyphenyl]ethenyl]-5-hydroxyphenyl

CAS号:

102841-42-9

分子式:

C26H32O14

分子量:

568.52

EINECS号:

相关类别:

标准品;植物提取物;标准品-中药标准品;植物药;对照品;中药对照品;植提标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;化工原料;其它酚类;标准品 -中药标准品;标准品，对照品;高纯分离试剂-标准品

Mol文件:

102841-42-9.mol

沸点 

954.7±65.0 °C(Predicted)

密度 

1.654

闪点 

531℃

酸度系数(pKa)

9.03±0.40(Predicted)

生物活性

Mulberroside A 是从 Morus alba 根的乙醇提取物中分离出的，具有抗酪氨酸酶和抗氧化活性，并被广泛用作化妆品中的活性成分。Mulberroside A 降低 TNF-α、IL-1β 和 IL-6 的表达并抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化。

靶点

Target Value TNF-α () IL-1β () IL-6 () NALP3 () Caspase-1 () 点击更多

Target

Value

TNF-α ()

IL-1β ()

IL-6 ()

NALP3 ()

Caspase-1 ()

点击更多

体内研究

Mulberroside A (10, 20, and 40 mg/kg) decreases serum uric acid levels and increases urinary urate excretion and fractional excretion of uric acid in hyperuricemic micem. Animal Model: Male Kun-Ming mice (20±2 g) Dosage: 5, 10, 20, and 40 mg/kg; the dose volume 10 mL/kg body weight Administration: Orally initiated at 9:00 a.m. Result: 10, 20, and 40 mg/kg significantly increased urinary urate excretion in 24 h, resulting in a remarkable elevation of fractional excretion of uric acid (FEUA), and the highest dose completely reversed FEUA alteration of hyperuricemic mice to normal.

Animal Model:

Male Kun-Ming mice (20±2 g)

Dosage:

5, 10, 20, and 40 mg/kg; the dose volume 10 mL/kg body weight

Administration:

Orally initiated at 9:00 a.m.

Result:

10, 20, and 40 mg/kg significantly increased urinary urate excretion in 24 h, resulting in a remarkable elevation of fractional excretion of uric acid (FEUA), and the highest dose completely reversed FEUA alteration of hyperuricemic mice to normal.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于桑白皮。

用途 

桑皮苷A具有镇咳平喘，抑制络氨酸酶，抗氧化活性等作用。

用途 

用于含量测定/鉴定/药理实验等 药理药效:镇咳平喘，抑制络氨酸酶，抗氧化活性等

海关编码 

29389090