黑海常春藤苷A1

中文名称:

黑海常春藤苷A1

中文同义词:

HEDERACOLCHISIDE A1(标准品);黑海常春藤苷A1;革叶常春藤皂苷A1;竹节香附皂苷R13;齐墩果酸-3-O-Α-L鼠李吡喃糖基-(1→2)[Β-D-葡萄吡喃糖基-(1→4)] -Α-L-吡喃阿拉伯糖苷;黑海常春藤皂苷A1;齐墩果酸-3-O-Β-D-吡喃鼠李糖基-(1→2)-[Β-D-吡喃葡萄糖基-(1→4)]-Α-L-吡喃阿拉伯糖苷

英文名称:

Hederacolchiside A1

英文同义词:

Hederacolchiside A1;HEDERACOLCHISIDE A1;;Raddeanoside R13;Olean-12-en-28-oicacid, 3-[(O-6-deoxy-a-L-mannopyranosyl-(12)-O-[b-D-glucopyranosyl-(14)]-a-L-arabinopyranosyl)oxy]-, (3b)-;Oleanolic acid-3-O-β-D-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)-]-α-L-arabinopyranoside，Hederacolchiside A1;Olean-12-en-28-oic acid, 3-[(O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl)oxy]-, (3β)-;Hederacolchiside A1 USP/EP/BP

CAS号:

106577-39-3

分子式:

C47H76O16

分子量:

897.1

EINECS号:

相关类别:

中药对照品;植物提取物;标准品;标准品-中药标准品;对照品;标准品 -中药标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;reagent;standard substance;Triterpenoids;三萜;标准品，对照品

Mol文件:

106577-39-3.mol

熔点 

253-255℃ (methanol , water )

沸点 

967.2±65.0 °C(Predicted)

密度 

1.36±0.1 g/cm3 (20 ºC 760 Torr)

酸度系数(pKa)

4?+-.0.70(Predicted)

生物活性

Hederacolchiside A1 是从白头翁中分离的，通过调节 PI3K/Akt/mTOR 信号通路诱导凋亡，从而抑制肿瘤细胞的增殖。Hederacolchiside A1 具有抗血吸虫病活性，影响体内和体外的寄生虫生存力。

靶点

PI3K Akt mTOR

PI3K

Akt

体外研究

Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher. Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) .

体内研究

hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model. Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells.