4-羟基查耳酮

中文名称:

4-羟基查耳酮

中文同义词:

4-羟基查耳酮;4-羟苯基苯丙烯酮

英文名称:

4-HYDROXYCHALCONE

英文同义词:

2-Benzal-4-hydroxyacetophenone 2-Benzylidene-4-hydroxyacetophenone;1-(4-Hydroxyphenyl)-3-phenyl-2-propen-1-one;1-(p-Hydroxyphenyl)-3-phenyl-2-propene-1-one;4-Hydroxychalcone,97%;4-Hydroxychalcone 98%;HYDROXYCHALCONE, 4-(RG);4-Hydroxychalcone98%;HYDROXYCHALCONE, 4-

CAS号:

2657-25-2

分子式:

C15H12O2

分子量:

224.25

EINECS号:

相关类别:

苯酚;植物提取物;中药对照品;Chalcones;Biochemistry;Flavonoids

Mol文件:

2657-25-2.mol

熔点 

174-178 °C

沸点 

419.6±45.0 °C(Predicted)

密度 

1.191±0.06 g/cm3(Predicted)

酸度系数(pKa)

7.72±0.15(Predicted)

BRN 

2049150

InChIKey

UAHGNXFYLAJDIN-IZZDOVSWSA-N

CAS 数据库

2657-25-2(CAS DataBase Reference)

生物活性

4-Hydroxychalcone (P-Cinnamoylphenol)，存在于草药、香料和茶叶中，是一种刺甘草查尔酮。它具有多种生物活性，能够抑制TNF-α诱导的NF-κB通路激活、并激活BMP信号通路。

靶点

Target Value NF-κB ()

Target

Value

NF-κB ()

体外研究

4-Hydroxychalcone (20-40 μM ; 2 hours) inhibits TNFα-induced (20 ng/mL; 6 hours) NF-kB pathway activation in a dose-dependent manner. 4-Hydroxychalcone (0.1-25 μM ; 8 hours) inhibits proteasome activity in a dose-dependent manner but has no effect on IKK activity. 4-Hydroxychalcone inhibits TNFα-dependent degradation of IkBα and subsequently prevents p50/p65 nuclear translocation leading to 4-Hydroxychalcone-inhibited expression of NF-kB target genes. 4-Hydroxychalcone affects cancer cell viability but has no significant effect on non-transformed cell viability. Cell Viability Assay Cell Line: K562 cells, Jurkat cells, U937 cells, PBMCs Concentration: 5 μM, 10 μM, 20 μM, 24 μM, 28 μM, 32 μM, 40 μM, 60 μM Incubation Time: 24 hours Result: Affected cancer cell viability but has no significant effect on non-transformed cell viability. Western Blot Analysis Cell Line: Jurkat cells Concentration: 60 μM (followed by TNFα 20 ng/mL ) Incubation Time: 2 hours Result: Inhibited TNFα -dependent degradation of IkBα and prevents p50/p65 nuclear translocation.

Cell Line:

K562 cells, Jurkat cells, U937 cells, PBMCs

Concentration:

5 μM, 10 μM, 20 μM, 24 μM, 28 μM, 32 μM, 40 μM, 60 μM

Incubation Time:

24 hours

Result:

Affected cancer cell viability but has no significant effect on non-transformed cell viability.

Cell Line:

Jurkat cells

Concentration:

60 μM (followed by TNFα 20 ng/mL )

Incubation Time:

2 hours

Result:

Inhibited TNFα -dependent degradation of IkBα and prevents p50/p65 nuclear translocation.

体内研究

4-Hydroxychalcone has hepatoprotective activity against Acetaminophen induced hepatotoxicity in mice. Animal Model: Male albino mice(5-30 g) Dosage: 25 mg/kg, 50 mg/kg, 100 mg/kg Administration: Oral administration, 12h intervals, 4 doses Result: Significantly reduced the mortality rate induced by Acetaminophen (1 g/kg).

Animal Model:

Male albino mice(5-30 g)

Dosage:

25 mg/kg, 50 mg/kg, 100 mg/kg

Administration:

Oral administration, 12h intervals, 4 doses

Result:

Significantly reduced the mortality rate induced by Acetaminophen (1 g/kg).

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

37/39-26-37

海关编码 

29145090