LJI308

中文名称:

LJI308

中文同义词:

RSK抑制剂(LJI308)

英文名称:

LJI308

英文同义词:

LJI308;LJI 308;LJI308;LJI-308;LJI 308;LJI308;CS-2181;2,6-Difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]phenol;Phenol, 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]-;LJI308 >=98% (HPLC)

CAS号:

1627709-94-7

分子式:

C21H18F2N2O2

分子量:

368.38

EINECS号:

604-604-1

相关类别:

细胞生物学试剂;抑制剂

Mol文件:

1627709-94-7.mol

储存条件 

Inert atmosphere,Store in freezer, under -20°C

生物活性

LJI308 是一种有效的泛 RSK 抑制剂，对 RSK1、RSK2 和 RSK3 的 IC50 分别为 6 nM、4 nM 和 13 nM。LJI308 抑制辐照、EGF 处理和 表达 KRAS 突变的细胞中 RSK (T359/S363) 和 YB-1 (S102) 的磷酸化。

体外研究

LJI308 inhibits S6K1 with an IC 50 of 0.8 μM. LJI308 inhibits YB-1 phosphorylation in CRC cells at concentrations of 5 to 25 μM. In a dose kinetics experiment, LJI308, starting at 2.5 μM, inhibits YB-1 phosphorylation in the KRAS mutated TNBC cell line MDA-MB-231 by approximately 86%. LJI308 effectively blocks RSK and YB-1 phosphorylation after EGF stimulation and after irradiation in KRAS wild-type HBL-100 cells. LJI308 (1-10 μM; 96 hours) decreases cell viability by up to 90%. Cell Viability Assay Cell Line: HTRY-LT cell lines Concentration: 1-10 μM Incubation Time: 96 hours Result: Decreased cell viability by up to 90%.

Cell Line:

HTRY-LT cell lines

Concentration:

1-10 μM

Incubation Time:

96 hours

Result:

Decreased cell viability by up to 90%.