奥马环素

中文名称:

奥马环素

中文同义词:

奥马环素;奥玛环素甲磺酸盐;OMADACYCLINE 奥马环素;对甲苯磺酸奥玛环素;奥玛环素(甲磺酸盐)试剂,湖北威德利优势供应产品;欢迎咨询张军;1.我们公司目前已经能够现货提供奥马环素科研精品试剂,提供科研项目开展所需的检测方法、质量标准;2.HPLC高效液相图谱、碳谱、氢谱和核磁图谱

英文名称:

OMadacycline (tosylate)

英文同义词:

QTH11;OMadacycline (tosylate);Omadacycline p-Toluenesulfonate;Amadacycline P-toluene sulfonate;Omadacycline tosylater;Superior products of Hubei wide Chemical Technology Co., Ltd;Welcome to consult Zhang Jun;10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepiner

CAS号:

1075240-43-5

分子式:

C36H48N4O10S

分子量:

728.85212

EINECS号:

相关类别:

医药原料药-科研原料;化学试剂;原料药;医药原料

Mol文件:

1075240-43-5.mol

生物活性

Omadacycline tosylate 是氨甲环素类抗生素，对革兰氏阳性和阴性的需氧菌以及一些厌氧菌具有抗菌活性。

靶点

bacteria

体外研究

Omadacycline displays activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), beta-hemolytic streptococci, penicillin-resistant Streptococcus pneumonia (PRSP) and Haemophilus influenzae (H. influenzae) , with MIC 90 s of 1.0, 0.25, 0.5, 0.25 and 2.0 μg/mL respectively. Omadacycline is active against strains expressing tetracycline and other antibiotics resistance by ribosomal protection and active tetracycline efflux.

体内研究

Omadacycline (0.11-18 mg/kg; a single i.v.) exhibits efficacy against Streptococcus pneumonia , Escherichia coli , and Staphylococcus aureus in mice systemic infection model, with ED 50 s ranging from 0.30 mg/kg to 3.39 mg/kg.