N-甲基-D-天冬氨酸

中文名称:

N-甲基-D-天冬氨酸

中文同义词:

N-甲基-D-天冬氨酸水合物;N-甲基-D-天门冬胺基乙酸;N-甲基-D-天(门)冬氨酸;N-甲基-D-天冬氨酸;N-甲基-D-天门冬氨酸, ≥97%;N-甲基-D-天门冬氨酸(CAS号:6384-92-5);N-甲基-D-天冬氨酸生产厂家;N-METHYL-D-ASPARTIC ACID聽

英文名称:

N-Methyl-D-aspartic acid

英文同义词:

N-METHYL-D-ASPARAGINIC ACID;N-METHYL-D-ASPARTIC ACID;N-METHYL-D-ASPARTIC ACID HYDROCHLORIDE;N-ME-D-ASPARTIC ACID;N-ME-D-ASP-OH;N-ME-D-ASP-OH HCL;NMDA;H-D-MEASP-OH

CAS号:

6384-92-5

分子式:

C5H9NO4

分子量:

147.13

EINECS号:

227-012-0

相关类别:

营养剂;神经信号;小分子抑制剂，天然产物;氨基酸及其衍生物;保护氨基酸;非天然氨基酸;氨基酸;Glutamate receptor;Glutamate;amino acids;Inhibitors;Pyridines;医药原料;原料

Mol文件:

6384-92-5.mol

熔点 

187-192 °C

比旋光度 

-28 º (c=1, HCl 6N)

沸点 

267.21°C (rough estimate)

密度 

1.4285 (rough estimate)

折射率 

-15 ° (C=2, H2O)

储存条件 

Sealed in dry,Room Temperature

酸度系数(pKa)

2.21±0.23(Predicted)

形态

solid

颜色

white

水溶解性 

slightly soluble

敏感性 

Hygroscopic

Merck 

14,6662

BRN 

1724431

CAS 数据库

6384-92-5(CAS DataBase Reference)

生物活性

NMDA (N-Methyl-D-aspartic acid)是一种特异性NMDA受体激动剂，通常作为受体，模拟神经递质谷氨酸的活性。Phase 4。

靶点

Target Value NMDA receptor

Target

Value

NMDA receptor

体外研究

NMDA是兴奋性氨基酸神经递质，只与NMDA受体结合，而不会影响其他谷氨酸受体（如AMPA和Kainate)。NMDA特异性与NMDA受体的NR2亚基结合，刺激非特异性阳离子通道的打开，使Ca

体内研究

NMDA (0.2 nM) shows significant effects on MF, IF, IL, and EL, respectively, decreasing the mount and intromission frequencies, and shortening the intromission and ejaculation latencies. NMDA and AP-5 significantly, respectively, facilitates and inhibits the ejaculatory behavior during the copulation testing 30 min. Bilateral microinjection of NMDA into PVN significantly increases the baseline LSNA, the peaking increment of LSNA occurred within 5 min from the time of NMDA microinjected into PVN.

用途 

释放细胞外毒性物质的氨基酸；具有调控离子通道的NMDA型谷氨酸酯受体原型兴奋剂，在长期势差、局部贫血以及癫痫等方面具有重要性

安全说明 

22-24/25

WGK Germany 

3

RTECS号

CI9457000

F 

10

海关编码 

29225090