中文同义词:
氨基-二聚乙二醇-丙酸叔丁酯;9-氨基-4,7-二氧杂壬酸叔丁酯 500MG;氨基-二乙二醇-丙酸叔丁酯;氨基-乙二醇-丙酸叔丁酯;氨基-聚乙二醇-丙酸叔丁酯;3-[2-(2-氨基乙氧基)乙氧基]丙酸叔丁酯;9-氨基-4,7-二氧杂壬酸叔丁酯;胺基-二聚乙二醇-丙酸叔丁酯
英文同义词:
H2N-PEG2-tBu;tert-Butyl 9-AMino-4,7-dioxanonanoate (H2N-PEG2-tBu) tert-butyl 9-AMino-4,7-dioxanonanoate;3-[2-(2-Aminoethoxy)ethoxy]propanoic acid 1,1-dimethylethyl ester;H2N-PEG2-CH2CH2COOtBu;Amino-PEG2-t-butyl ester;H2N-PEG2-CH2CH2COOtBu;Amino-PEG2-acid -t-Butyl ester;tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate
相关类别:
聚乙二醇修饰剂;PEG-COOtBu;ADCs Linkers
沸点
313.7±22.0 °C(Predicted)
密度
1.014±0.06 g/cm3(Predicted)
储存条件
Keep in dark place,Inert atmosphere,2-8°C
酸度系数(pKa)
8.74±0.10(Predicted)
生物活性
NH2-PEG2-C2-Boc 是一种 PROTAC linker,属于 PEG 类。NH2-PEG2-C2-Boc 可用于合成PROTAC分子。NH2-PEG2-C2-Boc 也是一种不可降解 (non-cleavable) 的含 2 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
靶点
PEGs
Alkyl/ether
Non-cleavable
体外研究
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.