隐陡头菌素S

中文名称:

隐陡头菌素S

中文同义词:

隐杯伞素;隐陡头菌素;月亮霉素;隐陡头菌素S

英文名称:

illudin S

英文同义词:

illudin S;(2S,3R,6R)-2,3-Dihydro-3,6-dihydroxy-2-hydroxymethyl-2,4,6-trimethylspiro[cyclopropane-1,5-[5H]inden]-7(6H)-one;Illusin S;Lampterol;NSC-626369;(1R,2S,5R)-1,5-dihydroxy-2-(hydroxymethyl)-2,5,7-trimethylspiro[1H-indene-6,1-cyclopropane]-4-one;Illudin;Illudine S

CAS号:

1149-99-1

分子式:

C15H20O4

分子量:

264.32

EINECS号:

相关类别:

微生物代谢物;ADC

Mol文件:

1149-99-1.mol

熔点 

124-126℃

沸点 

327.55°C (rough estimate)

密度 

1.0583 (rough estimate)

折射率 

1.4300 (estimate)

生物活性

Illudin S 是一种细胞毒性隐陡头菌素，是天然的倍半萜烯，具有高效的抗肿瘤和抗病毒活性。Illudin S 具有遗传毒性。Illudin S 在人类白血病细胞中阻断细胞循环的 G1/S 时相。

体外研究

Illudin S (0-0.26 nM; 24-72 hours) shows cytotoxicity in human fibroblasts. Cell Viability Assay Cell Line: Human fibroblasts Concentration: 0-0.26 nM Incubation Time: 24 hours, 72 hours Result: Decreased cell survival.

Cell Line:

Human fibroblasts

Concentration:

0-0.26 nM

Incubation Time:

24 hours, 72 hours

Result:

Decreased cell survival.