氨基-六聚乙二醇-叠氮

中文名称:

氨基-六聚乙二醇-叠氮

中文同义词:

氨基-六聚乙二醇-叠氮;O-(2-氨基乙基)-O`-(2-叠氮乙基)五乙二醇;O-(2-氨基乙基)-O′-(2-叠氮乙基)戊乙二醇;叠氮-PEG-胺(聚合度为 6);20-叠氮基-3,6,9,12,15,18-六氧杂二十烷-1-胺;AZIDO-PEG6-AMINE,N3-PEG6-NH2

英文名称:

20-Azido-3,6,9,12,15,18-hexaoxaeicosan-1-amine

英文同义词:

AZIDO-PEG-AMINE;2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine;O-(2-AMINOETHYL)-O-(2-AZIDOETHYL)HEPTAETHYLENE GLYCOL;O-(2-AMINOETHYL)-O-(2-AZIDOETHYL)NONAETHYLENE GLYCOL;O-(2-AMINOETHYL)-O-(2-AZIDOETHYL)PENTAETHYLENE GLYCOL;Azido-PEG-amine (n=6);O-(2-Aminoethyl)-O-(2-azidoethyl)pentaethylene glycol >=90% (oligomer purity);Azido-PEG6-amine

CAS号:

957486-82-7

分子式:

C22H46N4O10

分子量:

526.62

EINECS号:

相关类别:

聚乙二醇修饰剂;Heterobifunctional PEG;Aliphatics;Amines;Labeling and Diagnostics Reagents;Polyethyleneglycol Derivatives;Aliphatic Azides;Alkynes and Other Reagents;Azides;Building Blocks;Chemical Biology;Chemical Synthesis;Conjugation Chemistry: Azides;Heterobifunctional PEGs;High Oligomer Purity PEG;Materials Science;Nitrogen Compounds;Organic Building Blocks;PEG Azides;PEGylation;Poly(ethylene glycol) and Poly(ethylene oxide);Polymer Science

Mol文件:

957486-82-7.mol

储存条件 

2-8°C

InChIKey

RMNAJNJBCBFOKX-UHFFFAOYSA-N

生物活性

Azido-PEG6-amine 是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。Azido-PEG6-amine 也是一种不可降解 (non-cleavable) 的含 6 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。

靶点

PEGs Non-cleavable

PEGs

Non-cleavable

体外研究

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

26-36

WGK Germany 

3

F 

10-23