艾拉普林

中文名称:

艾拉普林

中文同义词:

艾拉普林;艾拉普林甲磺酸盐;5-[(2-环丙基-7,8-二甲氧基-2H-1-苯并吡喃-5-基)甲基]-2,4-嘧啶二胺

英文名称:

5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4- diamine

英文同义词:

5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4- diamine;iclaprim;AR 100;5-(2-Cyclopropyl-7,8-dimethoxy-2H-chromen-5-ylmethyl)-pyrimidine-2,4-diamine (ICLAPRIM];5-((2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl)pyrimidine-2,4-diamine(WXG01982);5-[(2-Cyclopropyl-7,8-diMethoxy-2H-1-benzopyran-5-yl)Methyl]-2,4-pyriMidine- diaMine;Iclaprim Methanesulfonate;2,4-Pyrimidinediamine, 5-[(2-cyclopropyl-7,8-dimethoxy-2H-1-benzopyran-5-yl)methyl]-

CAS号:

192314-93-5

分子式:

C19H22N4O3

分子量:

354.4

EINECS号:

相关类别:

Amines;Heterocycles;Inhibitors;Intermediates Fine Chemicals;Pharmaceuticals

Mol文件:

192314-93-5.mol

沸点 

616.7±65.0 °C(Predicted)

密度 

1.332±0.06 g/cm3(Predicted)

酸度系数(pKa)

7.07±0.10(Predicted)

生物活性

Iclaprim 是一种新的, 有选择性的细菌二氢叶酸抑制剂, 可以抑制金黄色葡萄球菌 (MRSA) 的生长, 其 MIC90 值为 0.06 μg/mL。

靶点

Dihydrofolate

体外研究

Iclaprim inhibits the growth of S. aureus (MRSA) with an MIC 90 of 0.06 μg/mL.