(+)-川白芷内酯

中文名称:

(+)-川白芷内酯

中文同义词:

(+)-川白芷内酯;白花前胡素 B;白花前胡素 B,(+)-川白芷内酯;白花前胡丁素,(+)-川白芷内酯;白花前胡丁素标准品;白花前胡丁素对照品

英文名称:

PDII

英文同义词:

PDII;(2Z,2Z)-2-Methyl-2-butenoic acid (9S,10S)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b]dipyran-9,10-diyl ester;Bis[(Z)-2-methyl-2-butenoic acid](9S,10S)-2-oxo-8,8-dimethyl-9,10-dihydro-2H,8H-benzo[1,2-b:3,4-b]dipyran-9β,10β-diyl ester;Bis[(Z)-2-methyl-2-butenoic acid][(9S,10S)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b]dipyran]-9,10-diyl ester;Praeruptorin B(b);2-Butenoic acid, 2-methyl-, (9S,10S)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b]dipyran-9,10-diyl ester, (2Z,2Z)-;8,8-dimethyl-9-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-9,10-dihydropyrano[2,3-f]chromen-10-yl](Z)-2-methylbut-2-enoate

CAS号:

73069-28-0

分子式:

C24H26O7

分子量:

426.46

EINECS号:

相关类别:

对照品-中药对照品;标准品 -中药标准品;标准品，对照品;对照品

Mol文件:

73069-28-0.mol

熔点 

175-176℃

沸点 

524.8±50.0 °C(Predicted)

密度 

1.24

生物活性

Praeruptorin B 是固醇调控元件结合蛋白 (SREBPs) 的抑制剂。

靶点

SREBP.

体外研究

Praeruptorin B inhibits the SREBPs activity and decreases intracellular lipid levels. Praeruptorin B is found to powerfully decrease the SRE-luciferase activity, and this effect is dose dependent. Praeruptorin B shows negligible cytotoxicity, even at the higher concentration. Praeruptorin B also significantlytly down-regulates the expression of SREBP-1c and SREBP-2 . Praeruptorin B also exhibits significant inhibition on the activity of UGT1A9.

体内研究

The mice treated with Praeruptorin B (50 mg/kg) are significantly lighter than the vehicle treated mice, although they are still heavier than the chow diet-fed mice, suggesting that Praeruptorin B can ameliorate diet-induced obesity (DIO). More importantly, the fat/lean and fat/body-weight ratios are obviously dropped at the same dosage of Praeruptorin B treated mice. It is also showed that the serum TC and TG levels of Praeruptorin B treated mice are significantly lower than those of the HFD-fed mice. Praeruptorin B increases HDL-c and decreases LDL-c similar as lovastatin. In addition, compared with vehicle treated mice, Praeruptorin B significantly lowers the level of TC and TG in liver, comparable to lovastatin. The staining results reveal that Praeruptorin B-treated mice exhibit less lipid accumulation than that of vehicle treated mice. The elevated fasting blood glucose and insulin in HFD-fed mice are significantly reduced by Praeruptorin B.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于白花前胡Peucedanumpraeruptorum的根。

用途 

白花前胡素 B具有祛痰； 扩血管、降血压的作用。

用途 

药理药效:祛痰、 扩血管、降血压