1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代哌啶-1-基)苯基]-4,5,6,7-四氢-1H-吡唑并[3,4-

中文名称:

1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代哌啶-1-基)苯基]-4,5,6,7-四氢-1H-吡唑并[3,4-C]吡啶-3-羧酸乙酯

中文同义词:

4,5,6,7-四氢-1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代-1-哌啶基)苯基]-1H-吡唑并[3,4-C]吡啶-3-羧酸乙酯;1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代哌啶-1-基)苯基]-4,5,6,7-四氢-1H-吡唑并[3,4-C]吡啶-3-羧酸乙酯;进口资料代码-BMS-589149-01;1H-吡唑并[3,4-C]吡啶-3-甲酸, 4,5,6,7-四氢-1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代-1-哌啶基)苯基]-, 乙酯;阿哌沙班杂质 9;1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代哌啶-1-基)苯基]-4,5,6,7-四氢-1H-吡唑并[3,4-C]吡啶-3-羧酸乙酯(阿哌沙班中间体) 1KG;阿哌沙班中间体C;阿哌沙班乙酯杂质

英文名称:

1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

英文同义词:

1H-Pyrazolo[3,4-c]pyridine-3-carboxylicacid,4,5,6,7-tetrahydro-1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-,ethylester;ethyl 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxylate;-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate;-7-oxo-6-(4-(2-oxopiperidin-1-yl);Ethyl 1-(4-methoxyphenyl);Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazo;1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester;4,5,6,7-Tetrahydro-1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1h-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

CAS号:

503614-91-3

分子式:

C27H28N4O5

分子量:

488.54

EINECS号:

700-890-7

相关类别:

抗凝血;标准品;对照品-杂质对照品;阿哌沙班;原料药;中间体;阿派沙班中间体;杂质对照品;医药原料;API;化工原料

Mol文件:

503614-91-3.mol

沸点 

758.7±60.0 °C(Predicted)

密度 

1.34

储存条件 

Sealed in dry,Room Temperature

酸度系数(pKa)

0.78±0.20(Predicted)

简介

1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代哌啶-1-基)苯基]-4，5，6，7-四氢-1H-吡唑并[3，4-C]吡啶-3-羧酸乙酯是制备阿哌沙班的中间体，阿哌沙班是一种抗血栓药物，它是由美国百时美-施贵宝和辉瑞公司共同开发的Xa因子直接抑制剂，于2011年3月在欧盟批准上市，并于2012年12月FDA批准了该药在美国上市。

用途

1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代哌啶-1-基)苯基]-4,5,6,7-四氢-1H-吡唑并[3,4-C]吡啶-3-羧酸乙酯用于药物瑞德西韦阿派沙班的合成制备中。