8-[2-氨基-6-[(4-溴-2-噻吩基)甲氧基]-9H-嘌呤-9-基]辛基 BETA-D-吡喃葡萄糖苷

中文名称:

8-[2-氨基-6-[(4-溴-2-噻吩基)甲氧基]-9H-嘌呤-9-基]辛基 BETA-D-吡喃葡萄糖苷

中文同义词:

8-[2-氨基-6-[(4-溴-2-噻吩基)甲氧基]-9H-嘌呤-9-基]辛基 BETA-D-吡喃葡萄糖苷;MGMT抑制剂(GLUCOSE-CONJUGATED MGMT INHIBITOR)

英文名称:

(2R,3R,4S,5S,6R)-2-((8-(2-aMino-6-((4-broMothiophen-2-yl)Methoxy)-9H-purin-9-yl)octyl)oxy)-6-(hydroxyMethyl)tetrahydro-2H-pyran-3,4,5-triol

英文同义词:

8-[2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purin-9-yl]octyl beta-D-glucopyranoside;(2R,3R,4S,5S,6R)-2-((8-(2-aMino-6-((4-broMothiophen-2-yl)Methoxy)-9H-purin-9-yl)octyl)oxy)-6-(hydroxyMethyl)tetrahydro-2H-pyran-3,4,5-triol;Glucose-conjugated MGMT inhibitor;β-D-Glucopyranoside, 8-[2-aMino-6-[(4-broMo-2-thienyl)Methoxy]-9H-purin-9-yl]octyl;O6BTG-octylglucoside;(2R,3R,4S,5S,6R)-2-[8-[2-amino-6-[(4-bromothiophen-2-yl)methoxy]purin-9-yl]octoxy]-6-(hydroxymethyl)oxane-3,4,5-triol;O6BTG-C8-βGlu

CAS号:

382607-78-5

分子式:

C24H34BrN5O7S

分子量:

616.53

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

382607-78-5.mol

沸点 

847.4±75.0 °C(Predicted)

密度 

1.70

酸度系数(pKa)

12.95±0.70(Predicted)

生物活性

O6BTG-octylglucoside 是一种有效的 MGMT 抑制剂，在细胞提取物及 HeLa S3 细胞中，IC50 值分别为 32 nM 和 10 nM。

靶点

MGMT 32 nM (IC 50 )

MGMT 32 nM (IC 50 )

体外研究

O6BTG-octylglucoside is a potent and non-toxic MGMT inhibitor, with IC 50 s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells.