F16

中文名称:

F16

中文同义词:

细胞增殖抑制剂(F16);4-[(E)-2-(1H-吲哚-3-基)乙烯基]-1-甲基吡啶鎓碘化物

英文名称:

F16

英文同义词:

F16;4-[(1E)-2-(1H-INDOL-3-YL)ETHENYL]-1-METHYL-PYRIDINIUM IODIDE;4-[(E)-2-(INDOL-3-YL)ETHENYL]-N-METHYLPYRIDINIUM IODIDE;F-16;COMPOUND F16;Compound F16);F16 (F-16;3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide;F16 (Neu-overexpressing?Cells?Inhibitor) (Fandachem)

CAS号:

36098-33-6

分子式:

C16H15IN2

分子量:

362.21

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

36098-33-6.mol

形态

Orange solid.

生物活性

F16 是 neu 过表达细胞的有效生长抑制剂，还可以选择性抑制乳腺上皮以及多种小鼠乳腺肿瘤和人乳腺癌细胞系的增殖。F16 是线粒体毒性化合物，根据靶癌细胞的遗传背景触发凋亡或坏死。

体外研究

F16 (3 μM; 3 days/7 days) affects growth in several mouse and human cancer cell lines. F16 arrests cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells. Cell Proliferation Assay Cell Line: MDA-MB231, MDA-MB435, MDA-MB436, MDA-MB453, MDA-MB-468, SKBR-3, MCF-7, T47D, ZR-75-1 cells and mouse mammary epithelial cell line NMuMG Concentration: 3 μM Incubation Time: 3 days/7 days Result: Displayed antiproliferative activity against both mouse and human breast cancer cells. The growth of the mouse fibrosarcoma cell lines derived from ras -transgenic mice was not affected.

Cell Line:

MDA-MB231, MDA-MB435, MDA-MB436, MDA-MB453, MDA-MB-468, SKBR-3, MCF-7, T47D, ZR-75-1 cells and mouse mammary epithelial cell line NMuMG

Concentration:

3 μM

Incubation Time:

3 days/7 days

Result:

Displayed antiproliferative activity against both mouse and human breast cancer cells. The growth of the mouse fibrosarcoma cell lines derived from ras -transgenic mice was not affected.