EPISILVESTROL

中文名称:

EPISILVESTROL

中文同义词:

5MYC-UTR-LUC抑制剂(EPISILVESTROL)

英文名称:

Episilvestrol

英文同义词:

Episilvestrol;(1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1S)-1,2-Dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylic acid methyl ester;1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 6-[[(2S,3R,6R)-6-[(1S)-1,2-dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3aR,8bS)-

CAS号:

697235-39-5

分子式:

C34H38O13

分子量:

654.66

EINECS号:

相关类别:

细胞生物学试剂;蛋白酪氨酸激酶

Mol文件:

697235-39-5.mol

生物活性

Episilvestrol 是 silvestrol 的衍生物，从 Aglaia silvestris 中分到，能够抑制 eIF4A 靶作用的转录过程。

靶点

eIF4A

体外研究

Episilvestrol is a specific eIF4A-targeting translation inhibitor, with antitumor activity. Episilvestrol is cytotoxic activity against several human cancer cell lines, such as Lu1, LNCaP, MCF-7 and HUVEC cells, with ED 50 s of 3.8, 3.8, 5.5 and 15.3 nM, respectively. The GI 50 s of Episilvestrol against the cell proliferation of NCI-H460 and MCF-7 cels are 17.96 nM and 17.96 nM after first test and 15.6 nM and 18.7 nM after 2 months via SRB assay. Episilvestrol also suppresses HK1 cells and EBV-positive C666.1 NPC cells.