1430218-51-1

中文名称:

1430218-51-1

中文同义词:

I型激酶抑制剂(VI 16832)

英文名称:

VI16832

英文同义词:

VI16832;Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-[[4-(2-aminoethoxy)phenyl]amino]-8-bicyclo[2.2.1]hept-2-yl-

CAS号:

1430218-51-1

分子式:

C22H25N5O2

分子量:

391.47

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

1430218-51-1.mol

沸点 

611.9±65.0 °C(Predicted)

密度 

1.337±0.06 g/cm3(Predicted)

酸度系数(pKa)

8.57±0.10(Predicted)

生物活性

VI 16832 是一种广谱的 I 型激酶抑制剂，可用作不同癌细胞系中蛋白激酶比较表达分析的富集工具。

靶点

Type I kinase

体外研究

VI 16832 is a broad spectrum Type I kinase inhibitor. Phosphoproteomics analysis of VI 16832-enriched fractions from MV4-11, HCT116, or 435S cells results in more than 8500 phosphopeptide identifications. These translate into almost 1700 distinct phosphopeptide species derived from 212 different members of the protein kinase superfamily. Analysis of VI 16832-retained proteins from the three cancer cell lines considerably increases the overall number of identified phosphorylation sites on protein kinases. Considering the sum of all phosphopeptide intensities as a measure for VI 16832-enriched protein amount, more than 80% is derived from protein kinases.