1189561-66-7

中文名称:

1189561-66-7

中文同义词:

BCL-2抑制剂((S)-GOSSYPOL ACETIC ACID)

英文名称:

(S)-Gossypol (acetic acid)

英文同义词:

(S)-Gossypol (acetic acid)

CAS号:

1189561-66-7

分子式:

分子量:

0

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

Mol File

CAS 数据库

1189561-66-7

生物活性

(S)-Gossypol acetic acid 是天然产物 Gossypol 的异构体。(S)-Gossypol 以高亲和力结合到 Bcl-xL 和 Bcl-2 蛋白的 BH3 结合沟。

靶点

Bcl-2 Bcl-xL

Bcl-2

Bcl-xL

体外研究

The natural racemic Gossypol has two enantiomers, namely the (-)-Gossypol and (S)-Gossypol ((+)-Gossypol) enantiomers. (+)-Gossypol and (-)-Gossypol binds to Bcl-2 or Bcl-xL with similar binding affinities. (-)-Gossypol is more potent than (+)-Gossypol in inhibition of cell growth and induction of apoptosis. The racemic form and each of the enantiomers of Gossypol are tested against UM-SCC-6 and UM-SCC-14A in 6-day MTT assays. (-)-Gossypol exhibits greater growth inhibition relative to (±)-Gossypol than (+)-Gossypol in both cell lines tested (P<0.001). An intermediate growth inhibitory effect is observed with (±)-Gossypol but this effect is only observed at the higher dose of Gossypol (10 μM, P<0.0001).