1402821-24-2

中文名称:

1402821-24-2

中文同义词:

CDK2抑制剂(CA2+ CHANNEL AGONIST 1)

英文名称:

Ca2+ channel agonist 1

英文同义词:

Ca2+ channel agonist 1;1-Butanol, 2-[[6-[(phenylmethyl)amino]-9-propyl-9H-purin-2-yl]amino]-, (2R)-

CAS号:

1402821-24-2

分子式:

C19H26N6O

分子量:

354.45

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

1402821-24-2.mol

生物活性

Ca2+ channel agonist 1 是一种 N-型钙离子通道 (N-type Ca2+ channel) 激动剂和 Cdk2 的抑制剂，EC50 分别为 14.23 μM 和 3.34 μM，对运动神经终端功能障碍有潜在疗效。

靶点

CDK2 3.34 μM (EC 50 ) N-Type Ca 2+ Channel 14.23 μM (EC 50 )

CDK2 3.34 μM (EC 50 )

N-Type Ca 2+ Channel 14.23 μM (EC 50 )

体外研究

Ca 2+ channel agonist 1 (Compound 13d) is an agonist of N-type Ca 2+ channel and an inhibitor of Cdk2, with EC 50 s of 14.23 μM and 3.34 μM, respectively. Ca 2+ channel agonist 1 exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.