1338780-86-1

中文名称:

1338780-86-1

中文同义词:

结核分枝杆菌金刚烷脲尿素抑制剂(AU1235)

英文名称:

AU1235

英文同义词:

AU1235;AU1235;AU-1235;AU 1235;Urea, N-tricyclo[3.3.1.13,7]dec-1-yl-N-(2,3,4-trifluorophenyl)-

CAS号:

1338780-86-1

分子式:

C17H19F3N2O

分子量:

324.34

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

1338780-86-1.mol

生物活性

AU1235 是一种金刚烷基尿素，是 Mycobacterium tuberculosis 蛋白 MmpL3 的有效抑制剂。

靶点

Target Value MmpL3 ()

Target

Value

MmpL3 ()

体外研究

AU1235 is similarly active against MDR isolates of M. tb displaying resistance to isoniazid, rifampicin, and pyrazinamide in addition to streptomycin, fluoroquinolones and/or ethambutol. AU1235 also inhibits Mycobacterium smegmatis and Mycobacterium fortuitum although the MICs (3.2 to 6.4 μg/ml) are significantly higher than against M. tb and M. bovis BCG.