苦参醇K

中文名称:

苦参醇K

中文同义词:

苦参醇K;苦参醇K标准品;苦参醇K对照品

英文名称:

Kushenol K

英文同义词:

Kushenol K;(2R,3S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-4H-1-benzopyran-4-one;product/154906;4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2R,3S)-

CAS号:

101236-49-1

分子式:

C26H32O8

分子量:

472.53

EINECS号:

相关类别:

植物提取物;中药对照品;对照品;标准品 -中药标准品;标准品，对照品;标准品

Mol文件:

101236-49-1.mol

生物活性

Kushenol K，一种从 Sophora flavescens 中提取的黄酮类抗氧化剂。Kushenol K 是 CYP3A4 的抑制剂，Ki 值为 1.35 μM。Kushenol K 对 HSV-2 具有较弱的抗病毒活性 (EC50 为 147 μM)。Kushenol K 还抑制 SGLT1 和 SGLT2 的活性。

靶点

HSV-2 147 μM (EC 50 ) CYP3A4 1.35 μM (Ki) SGLT

HSV-2 147 μM (EC 50 )

CYP3A4 1.35 μM (Ki)

体外研究

When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC 50 values of 1.62 µM. At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%.