1581270-11-2

中文名称:

1581270-11-2

中文同义词:

RIP2抑制剂(RIP2 KINASE INHIBITOR 2)

英文名称:

RIP2 kinase inhibitor 2

英文同义词:

RIP2 kinase inhibitor 2;RIPK2-IN-2;RIP2 kise inhibitor 2;4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-(2-methoxyethoxy)-

CAS号:

1581270-11-2

分子式:

C21H28N4O4S

分子量:

432.54

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

1581270-11-2.mol

沸点 

670.0±55.0 °C(Predicted)

密度 

1.266±0.06 g/cm3(Predicted)

酸度系数(pKa)

14.93±0.50(Predicted)

生物活性

RIP2 kinase inhibitor 2 是一种受体相互作用蛋白-2 (RIP2) 激酶抑制剂，详细信息请参考专利 WO/2014043437 A1 中的化合物 example 9。

靶点

RIP2 Kinase

体外研究

RIP2 kinase inhibitor 2 is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase is a TKL family serine/threonine protein kinase involved in innate immune signaling. Following activation, RIP2 kinase associates with NODI or NOD2 and appears to function principally as a molecular scaffold to bring together other kinases (TAK1, ΙΚΚα/β/γ) involved in NF-κΒ and mitogen-activated protein kinase activation.