303126-97-8

中文名称:

303126-97-8

中文同义词:

化合物SR0987

英文名称:

SR 0987

英文同义词:

SR 0987;2-chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide;2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide;SR 0987;SR-0987;SR0987;303126-97-8;Benzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-;SR0987 >=98% (HPLC)

CAS号:

303126-97-8

分子式:

C16H10ClF6NO2

分子量:

397.7

EINECS号:

相关类别:

API

Mol文件:

303126-97-8.mol

沸点 

378.8±42.0 °C(Predicted)

密度 

1.525±0.06 g/cm3(Predicted)

储存条件 

Sealed in dry,Store in freezer, under -20°C

酸度系数(pKa)

9.22±0.15(Predicted)

生物活性

SR 0987 是一种SR 1078的类似物，是 T cell-specific RORγ (RORγt) 的激动剂，EC50值为800 nM。SR 0987 可抑制 PD-1，生成 IL17，并具有治疗癌症的潜力。

靶点

Target Value PD-1 () IL17 () RORγt (Cell-free assay) 800 nM(EC50)

Target

Value

PD-1 ()

IL17 ()

RORγt (Cell-free assay)

800 nM(EC50)

体外研究

SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC 50 of ~800nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production.