4-O-甲基刺甘草查尔酮

中文名称:

4-O-甲基刺甘草查尔酮

中文同义词:

4-O-甲基刺甘草查尔酮

英文名称:

4-Hydroxy-2,4-dimethoxychalcone

英文同义词:

4-Hydroxy-2,4-dimethoxychalcone;2-Propen-1-one, 3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)-;4-O-Methylechinatin

CAS号:

151135-64-7

分子式:

C17H16O4

分子量:

284.31

EINECS号:

相关类别:

中药对照品;查尔酮

Mol文件:

151135-64-7.mol

生物活性

4-Hydroxy-2,4-dimethoxychalcone 是龙血天竺葵红色草药树脂中的天然查尔酮衍生物。4-Hydroxy-2,4-dimethoxychalcone 具有广泛的生物学活性，包括抗疟疾，抗原生动物，抗细菌，抗真菌活性。

体外研究

4-Hydroxy-2,4-dimethoxychalcone (compound 2) is against P. falciparum D6 (IC 50 =4.2 μM) and W2 (IC 50 =4.8 μM).

体内研究

4-Hydroxy-2,4-dimethoxychalcone (compound 2; oral; 160 mg/kg) has a T 1/2 of 1.94 hours, a C max of 158 ng/mL and an AUC of 384 ng•h/mL in four- to five-week-old ICR mice.