1599432-18-4

中文名称:

1599432-18-4

中文同义词:

依鲁替尼生物素;BTK抑制剂(IBRUTINIB-BIOTIN)

英文名称:

Ibrutinib-biotin

英文同义词:

Ibrutinib-biotin;Ibrutinib-biotin-1;Reaxys ID: 26833452;Pentanediamide, N1-[4-[[4-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-4-oxo-2-buten-1-yl]methylamino]butyl]-N5-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-trioxa-14-azanonadec-1-yl]-

CAS号:

1599432-18-4

分子式:

C56H80N12O9S

分子量:

1097.37

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

1599432-18-4.mol

沸点 

1288.9±65.0 °C(Predicted)

密度 

1.33±0.1 g/cm3(Predicted)

酸度系数(pKa)

13.90±0.40(Predicted)

生物活性

Ibrutinib-biotin 是一种由 Ibrutinib 通过长链接头连接到生物素上组成的探针，具体可参考 WO2014059368A1 中 Compound 1-5，抑制 BTK，IC50 值为 0.755-1.02 nM。

靶点

IC50: 0.755-1.02 nM (BTK), 1.71-2.29 nM (TEC), 3.66-4.27 nM (BLK), 4.42-5.57 nM (BMX), 5.99-6.92 nM (LCK), 33.8-36.3 nM (Src), 0.187-0.198 μM (ITK),5.34-4.87 μM (JAK3)

体外研究

Ibrutinib-biotin (Compound 1-5) is a probe that consists of Ibrutinib linked to biotin via a long chain linker. Ibrutinib is a TEC family kinase inhibitor. The TEC kinase family is composed of five members, TEC, BTK (Brutons Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX and TXK/RLK. The TEC family kinases participate in phosphotyrosine- mediated and phospholipid-mediated signaling systems. Many TEC family proteins are abundantly expressed in hematopoietic tissues, and play important roles in the growth and differentiation processes of blood cells.