2-CL-IB-MECA

中文名称:

2-CL-IB-MECA

中文同义词:

1-[2-氯-6-[[(3-碘苯基)甲基]氨基]-9H-嘌呤-9-基]-1-脱氧-N-甲基-BETA-D-呋喃核糖酰胺;氯-IB-MECA;A3ADENOSINE受体激动剂(2-CL-IB-MECA);2-氯-N6-(3-碘苄基)腺苷-5-N-甲基脲酰胺;1-[2-氯-6-[[(3-碘苯基)甲基]氨基]-9H-嘌呤-9-基]-1-脱氧-N-甲基-BETA-D-呋喃核糖酰胺 FU;2-CL-IB-MECA游离态

英文名称:

1-[2-CHLORO-6-[[(3-IODOPHENYL)METHYL]AMINO]-9H-PURIN-9-YL]-1-DEOXY-N-METHYL-BETA-D-RIBOFURANURONAMIDE

英文同义词:

2-CL-IB-MECA;1-[2-CHLORO-6-[[(3-IODOPHENYL)METHYL]AMINO]-9H-PURIN-9-YL]-1-DEOXY-N-METHYL-BETA-D-RIBOFURANURONAMIDE;1-(2-Chloro-6-(((3-iodophenyl)methyl)amino)-(9H)-purin-9-yl)-1-deoxy-N-methyl-beta-D-ribofuranuronamide;Cl-IB-MECA, 2-Chloro-N6-(3-iodobenzyl)-adenosine-5μ-N-methyluronamide;1-[2-Chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide;1-[2-CHLORO-6-[[(3-IODOPHENYL)METHYL]AMINO]-9H-PURIN-9-YL]-1-DEOXY-N-METHYL-β-D-RIBOFURANURONAMIDE 2-Cl-IB-Meca;b-D-RibofuranuronaMide,1-[2-chloro-6-[[(3-iodophenyl)Methyl]aMino]-9H-purin-9-yl]-1-deoxy-N-Methyl-;CF-102

CAS号:

163042-96-4

分子式:

C18H18ClIN6O4

分子量:

544.73

EINECS号:

相关类别:

化学试剂;细胞生物学试剂

Mol文件:

163042-96-4.mol

熔点 

209 °C

密度 

2.04±0.1 g/cm3 (20 ºC 760 Torr)

储存条件 

Keep in dark place,Inert atmosphere,2-8°C

溶解度 

DMSO: >20mg/mL

形态

solid

酸度系数(pKa)

12.68±0.70(Predicted)

颜色

white

用途

2-Cl-IB-MECA用作充当A3腺苷受体选择性核苷。

生物活性

Namodenoson (CF-102, 2-Cl-IB-MECA) 是一种口服生物利用的 A3 adenosine receptor (A3AR) 的选择性激动剂，Ki值为0.33 nM。Namodenoson 具有使PI3K/NF‑κB/Wnt/β‑catenin信号通路失调来介导的抗NASH作用。

靶点

Target Value A3AR (Cell-free assay) 0.33 nM(Ki)

Target

Value

A3AR (Cell-free assay)

0.33 nM(Ki)

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

26-36

WGK Germany 

3