埃索美拉唑镁(三水)

中文名称:

埃索美拉唑镁(三水)

中文同义词:

埃索美拉唑镁水合物;三水埃索美拉唑镁;埃索美拉唑镁三水合物;埃索美拉唑三水镁盐;二(5-甲氧基-2-[(S)-[(4-甲氧基-3,5-二甲基-2-吡啶基)甲基]亚磺酰基]-1H-苯并咪唑-1-基)镁盐三水合物;埃索美拉唑镁(三水);埃索美拉唑镁三水化合物;埃索美拉唑镁(艾司奥美拉唑镁)

英文名称:

Esomeprazole magnesium trihydrate

英文同义词:

ESOMEPRAZOLE MAGNESIUM TRIHYDRATE;bis(5-methoxy-2-[(s)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1h-benzylimidazole-1-yl) magnesium trihydrate;(T-4)-Bis[5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazolato]magnesium;Nexium;ESOPMEPRAZOLE MG TRIHYDRATE;5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]benzimidazol-1-ide;5-methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]benzimidazol-1-ide;5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide

CAS号:

217087-09-7

分子式:

C34H38MgN6O7S2

分子量:

731.14

EINECS号:

669-839-3

相关类别:

原料药;消化系统用药;标准品;医用原料;原料中间体-原料药;医药原料药-科研原料;特色原料;Chiral Reagents;Inhibitors;Acid pump inhibitors;埃索美拉唑钠;医药原料;中间体;医药中间体;胃病用药;埃索美拉唑钠中间体;医用原料;杂质对照品;其他原料;埃索美拉唑镁三水合物;有机化学;Intermediates Fine Chemicals;Pharmaceuticals

Mol文件:

217087-09-7.mol

熔点 

184-189°C (dec.)

储存条件 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度 

Slightly soluble in water, soluble in methanol, practically insoluble in heptane.

形态

neat

InChIKey

VEVZQDGATGBLIC-UHFFFAOYSA-N

CAS 数据库

217087-09-7(CAS DataBase Reference)

用途

奥美拉唑的S形式。胃质子泵抑制剂。

生物活性

Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) 是一种有效的具有口服活性 H+, K+-ATPase 抑制剂，可用于上消化道疾病和胃食管反流疾病的研究。Esomeprazole magnesium trihydrate 是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。

靶点

H + , K + -ATPase

体外研究

Esomeprazole magnesium trihydrate is develped from Esomeprazole strontium tetrahydrate (EST). EST contains esomeprazole, the S-enantiomer of omeprazole a salt-exchanged version of Esomeprazole magnesium trihydrate.

体内研究

Esomeprazole magnesium (0.5-50 mg/kg; oral gavage; daily; for 10 days; A/J mice) treatment increases gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity. Animal Model: A/J mice Dosage: 0.5 mg/kg, 5 mg/kg, 50 mg/kg Administration: Oral gavage; daily; for 10 days Result: Gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity are increased.

Animal Model:

A/J mice

Dosage:

0.5 mg/kg, 5 mg/kg, 50 mg/kg

Administration:

Oral gavage; daily; for 10 days

Result:

Gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity are increased.

用途 

胃食管反流性胃病用药

用途 

是一种新型质子泵抑制剂，可抑制H+/K+-ATP酶活性，临床主要用于治疗胃酸分泌过多引起的胃溃疡、十二指肠溃疡及反流性食管炎等消化系统疾病。

危险品标志 

Xn

危险类别码 

22

WGK Germany 

3

海关编码 

2933399090