globomycin

中文名称:

globomycin

中文同义词:

英文名称:

globomycin

英文同义词:

globomycin;Antibiotic SF-1902A1;Cyclo[Gly-[(2R,3R)-3-hydroxy*-2-methyl-1-oxononyl]-N-methyl-L-Leu-L-aIle-L-Ser-L-aThr-];SF-1902A1;Globomycin from Streptomyces hagronensis;Glycine, N-(N-(N-(N-(N-(3-hydroxy-2-methyl-1-oxononyl)-N-methylleucyl)-L-alloisoleucyl)-L-seryl)-L-allothreonyl)-, rho-lactone;SF 1902

CAS号:

67076-74-8

分子式:

C32H57N5O9

分子量:

655.828

EINECS号:

相关类别:

环肽

Mol文件:

67076-74-8.mol

储存条件 

-20°C

溶解度 

DMSO: soluble1mg/mL

形态

powder

颜色

white

生物活性

Globomycin 是一种脂肽抗生素，也是一种信号肽酶 II ( LspA) 抑制剂。Globomycin 通过不可逆地结合肽酶来抑制原脂蛋白的加工。Globomycin 对 Spiroplasma melliferum 有毒性，其 MIC 在 6.25-12.5 μM 范围内。

靶点

Signal peptidase II (LspA) Gram-negative/Gram-positive bacteria

体外研究

Globomycin is capable of inhibiting the growth of S. melliferum. The MICs are 6.25 µM (4.1 µg/mL) for strain BC3 and 12.5 µM (8.2 µg/mL) for strain B88. Globomycin can interfere with the processing of bacterial lipoproteins by inhibition of signal peptidase II in gracilicutes (Gram-negative eubacteria) and firmicutes (Gram-positive eubacteria). In B. diminuta DS010 cells, in the Globomycin-treated cultures most of the organophosphate hydrolase (OPH) accumulates in the cytoplasmic fraction in an unprocessed form. This is in contrast with the untreated cells where very little precursor was detectable. Moreover, there is substantially less mature OPH detectable in the membrane fraction following Globomycin treatment. The OPH signal peptide contains an invariant cysteine residue at the junction of the signal peptidase (Spase) cleavage site along with a well conserved lipobox motif. Substitution of the conserved lipobox cysteine to serine resulted in release of OPH into the periplasm, confirming that OPH is a lipoprotein.

WGK Germany 

3

RTECS号

MC0593500