2-((1-((3,6-DIHYDROXY-3-OXO-3H-SPIRO[ISOBENZOFURAN-1,9,-XANT

中文名称:

2-((1-((3,6-DIHYDROXY-3-OXO-3H-SPIRO[ISOBENZOFURAN-1,9,-XANTHEN]-5-YL)AMINO)-1-THIOXO-6,9,12,15,18-PENTAOXA-2-AZAHENICOSAN-21-YL)AMINO)-4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL)BENZAMIDE,HS-27

中文同义词:

HS27细胞:人皮肤成纤维细胞系;HS27 人皮肤成纤维细胞系;人包皮皮肤成纤维细胞;2-((1-((3,6-DIHYDROXY-3-OXO-3H-SPIRO[ISOBENZOFURAN-1,9,-XANTHEN]-5-YL)AMINO)-1-THIOXO-6,9,12,15,18;HS27人皮肤成纤维复苏细胞(附STR鉴定报告)

英文名称:

Hs 27

英文同义词:

Hs 27;2-((1-((3,6-DIHYDROXY-3-OXO-3H-SPIRO[ISOBENZOFURAN-1,9,-XANTHEN]-5-YL)AMINO)-1-THIOXO-6,9,12,15,18-PENTAOXA-2-AZAHENICOSAN-21-YL)AMINO)-4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL)BENZAMIDE,HS-27;HS27;HS-27;HS 27;Benzamide, 2-[[21-[(3,6-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9-[9H]xanthen]-5-yl)amino]-21-thioxo-4,7,10,13,16-pentaoxa-20-azaheneicos-1-yl]amino]-4-(4,5,6,7-tetrahydro-3,6,6-trimethyl-4-oxo-1H-indazol-1-yl)-;2-((1-((3,6-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9,-xanthen]-5-yl)amino)-1-thio,HS-27

CAS号:

1562024-11-6

分子式:

C52H60N6O12S

分子量:

993.13

EINECS号:

相关类别:

生物试剂

Mol文件:

1562024-11-6.mol

沸点 

1095.1±75.0 °C(Predicted)

密度 

1.39±0.1 g/cm3(Predicted)

储存条件 

-196°C

酸度系数(pKa)

9.33±0.20(Predicted)

生物活性

HS-27，一种荧光 Hsp90 抑制剂，检测完整组织标本表面 Hsp90 的表达。HS-27 由 SNX-5422 的核心元素组成，SNX-5422 是一种 Hsp90 抑制剂，通过 PEG 连接物与荧光素衍生物 (异硫氰酸荧光素或 FITC) 连接，后者与外周表达的 Hsp90 结合。HS-27 在乳腺癌的观察与研究中有潜在的应用。

靶点

HSP90

HSP90

体外研究

HS-27 labels all receptor subtypes of breast cancer, but not normal cells, and specifically binds to Hsp90 expressed on the surface of breast cancer cells before being internalized. HS-27 fluorescence is greater in tumor than non-tumor tissue.