H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH, (Disulfide

中文名称:

H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH, (Disulfide bond)

中文同义词:

英文名称:

H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH, (Disulfide bond)

英文同义词:

H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH, (Disulfide bond);Transdermal Peptide (TD 1 peptide);TD 1 (peptide);Glycine, L-alanyl-L-cysteinyl-L-seryl-L-seryl-L-seryl-L-prolyl-L-seryl-L-lysyl-L-histidyl-L-cysteinyl-, cyclic (2→10)-disulfide (9CI);Transdermal Peptide Disulfide

CAS号:

888486-23-5

分子式:

C40H64N14O16S2

分子量:

1061.15

EINECS号:

相关类别:

多肽

Mol文件:

888486-23-5.mol

沸点 

1728.7±65.0 °C(Predicted)

密度 

1.54±0.1 g/cm3(Predicted)

酸度系数(pKa)

3.57±0.10(Predicted)

生物活性

Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) 是由 11 个氨基酸组成的多肽，可以与 Na+/K+-ATPase beta-subunit (ATP1B1) 结合，主要与 ATP1B1 的 C 末端相互作用。Transdermal Peptide Disulfide 能够增强一些大分子在皮肤中的传递。

体外研究

In the presence of Transdermal Peptide Disulfide, because of the specific binding of Transdermal Peptide Disulfide to ATP1B1, cells will upregulate the level of ATP1B1 to maintain function and structure; as a result, the expression of ATP1B1 increases. However, as time goes on, some Transdermal Peptide Disulfide molecules may be transported into cells by endocytosis; consequently, the expression of ATP1B1 then decreases. The interaction between Transdermal Peptide Disulfide and ATP1B1 changes not only the expression of ATP1B1, but also the localization of ATP1B1 and then the structure of the epidermal layer. This interaction can be attenuated by inhibitors or competitors, which would result in the reduced delivery of macromolecular drugs across the skin.