PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG

中文名称:

PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG

中文同义词:

去-精氨酰-血管舒缓激肽;舒缓激肽片段2-9;BRADYKININ (2-9) (SYNONYMS: DES-ARG1-BRADYKININ)

英文名称:

PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG

英文同义词:

BRADYKININ, FRAGMENT 2-9;BRADYKININ (2-9);(DES-ARG1)-BRADYKININ;H-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG-OH;PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG;PPGFSPFR;1-DE-L-ARGININE-BRADYKININ;L-Pro-L-Pro-Gly-L-Phe-L-Ser-L-Pro-L-Phe-L-Arg-OH

CAS号:

16875-11-9

分子式:

C44H61N11O10

分子量:

904.02

EINECS号:

相关类别:

多肽;细胞信号和神经生物学;细胞生物学;Peptide;BradykininsPeptides and Proteins;Bradykinins;Neuropeptides;Peptides for Cell Biology

Mol文件:

16875-11-9.mol

密度 

1.46±0.1 g/cm3(Predicted)

储存条件 

−20°C

形态

White to off-white powder.

酸度系数(pKa)

3.34±0.10(Predicted)

生物活性

Bradykinin (2-9) 是一种氨基截短的激肽肽。Bradykinin (2-9) 是由氨基肽酶 P 切割形成的一种 Bradykinin 代谢物。

体外研究

The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8).

WGK Germany 

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